Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 11 fantasy matchups.
Pittsburgh Steelers at Cleveland Browns: 1:00 p.m. ET on CBS
Ben Roethlisberger, QB -- START: Despite losing his last two games since returning from a knee injury, Big Ben has posted no fewer than 18 fantasy points in either contest. He racked up 408 passing yards last week against a Dallas defense that had been surrendering just 220.6 pass yards per game coming into Week 9. Although the game against the Browns is on the road, Ben should have no issues producing against a defense that ranks last or second-to-last in the league in nearly every relevant statistic.
Le'Veon Bell, RB -- START: We finally saw Bell break the plane last week ... twice. And although he's had fewer than 85 rushing yards in each of his last five games, Bell racks up fantasy points via receptions, with 100-plus scrimmage yards in five of his last six. He's a no-brainer elite RB1 against a pathetic Browns defense.
Antonio Brown, WR -- START: Brown has collected 11-plus targets in each of his last three games and is averaging 140 yards per game in each of his last four contests against Cleveland. He has a chance to be the highest scoring wideout of the week.
Eli Rogers, WR -- FLEX: Rogers has 15 targets, 10 receptions and 20.5 standard fantasy points in his last two games. He's playing a bigger role with Sammie Coates, who played just two snaps last week, still ailing from finger injuries. Rogers is a sneaky flex play against a soft Cleveland secondary.
Steelers TEs -- SIT: Until we see it come together on the field for Ladarius Green, we preach caution with using him. This could be the week though, since the Browns are absolutely awful at stopping all pass-catchers, but against tight ends in particular. Jesse James hasn't been producing enough in recent weeks to risk using him.
Isaiah Crowell, RB -- FLEX: Pittsburgh has allowed a 100-yard rusher in three of their last four games. Crowell has some flex appeal as the lead back and goal-line guy for Cleveland (if they can get there). But if they get down early, Crowell could suffer from a poor game script.
Duke Johnson, RB -- SIT: Johnson's had single-digit touch totals in each of his last two games and simply isn't being used enough to warrant a fantasy start.
Terrelle Pryor, WR -- START: Pryor is tough to keep on the bench since he leads Cleveland in targets, receptions, receiving yards and receiving touchdowns this year. Still, it's reasonable to worry about who's getting him the ball. But in yet another game in which the Browns should fall behind early, Pryor makes for a volume play against a questionable Steelers secondary.
Corey Coleman, WR -- LOW-END FLEX: Coleman hasn't been much of a factor since returning two weeks ago from a hand injury. But in the same way that Pryor makes for a volume upside play, Coleman should be able to produce better numbers than he did last week (17 yards).
Baltimore Ravens at Dallas Cowboys: 1:00 p.m. ET on CBS
Joe Flacco, QB -- SIT: For the most part it's been a drag chasing Flacco's good games. Pass on him going against a Dallas team that allows their opponents to run the third-fewest plays in the NFL.
Ravens RBs -- FLEX: You probably want to break ties against having these players in your lineup, but running back options aren't plentiful. West still saw 21 carries last week, and while he won't get that kind of work against Dallas, he could get going in spurts against a front that allows 4.3 yards per carry on the year. Kenneth Dixon only makes sense in PPR formats (five catches last week) as a dart throw.
Steve Smith, WR -- FLEX: Dallas allowed their first 100-yard receiver of the season last week. That impressive streak was made possible because of the limited possessions and drives they cede to opponents. The Cowboys rank 28th in yards per game allowed to the wide receiver position, which exposes Smith to a low floor.
Dennis Pitta, TE -- SIT: At some point he's going to score, but it's getting increasingly difficult to chase. Pitta had a mere 1.7 average depth of target last week and caught six passes for under 30 yards.
Dak Prescott, QB -- START: Officially installed as the starter going forward, Prescott is still a fringe every-week fantasy starter. The Ravens defense is no joke, however, as their 16-to-11 touchdown-to-interception ratio is one of the best in the NFL and they've allowed just 213 passing yards per game over the last month.
Dez Bryant, WR -- START: There's that one catch, 19-yard clunker stuck between two elite games for Bryant since his return from injury. It's an understandable worry for him to post a similar line again. However, his week-winning potential is impossible to turn away from.
Jacksonville Jaguars at Detroit Lions: 1:00 p.m. ET on CBS
Jaguars RBs -- SIT: It looks like their solid outing against the Chiefs was an aberration. Both T.J. Yeldon (9-32) and Chris Ivory (9-31) had nearly identical mediocre lines in Week 10. After being one of the softer fronts to start the year, the Lions have allowed just 3.7 yards per carry over the last month.
Marqise Lee, WR -- FLEX: Lee has target totals of six, eight, three, eight and six in his last five games. He gets the easy, high-percentage targets on short routes in the middle of the field. If you need a safe floor play in your flex, this is a good week for Lee.
Julius Thomas, TE -- SIT: Yes, every tight end scores touchdowns against the Lions, but playing Thomas couldn't possibly be riskier. After playing 83 and 81 percent of the team snaps in Weeks 6 and 7, the team has taken more off his plate of late. In his last three games he's played 47, 55 and 53 percent of the snaps. Good luck.
Golden Tate, WR -- START: It's impossible to sit Tate right now. He had target totals of 10, 12, nine and 12 in the four games heading into his bye week.
Anquan Boldin, WR -- FLEX: You could do a lot worse than Boldin if you're in a pinch at wideout. He's been a 78 percent snap share player in their last four games and has scored on four of his eight red-zone targets this season.
Eric Ebron, TE -- START: After a multi-week absence, Ebron returned in Weeks 8 and 9 to handle 16 targets (second-most on the team in that span), which he turned into 12 catches and 146 yards. The Jaguars tight end defense is starting to slip, as 59.9 percent of their yards allowed to the positon have come in their last four games alone.
Tennessee Titans at Indianapolis Colts: 1:00 p.m. ET on CBS
Marcus Mariota, QB -- START: Since Week 5, Mariota's 17 touchdown passes is the most in the NFL. He's posted 25-plus fantasy points in four of his last six games. You weren't even thinking about sitting him, were you?
Rishard Matthews, WR -- START: Matthews has been a vital part of Mariota's recent hot streak, and has scored six touchdowns in his last six games. The yardage totals haven't been there but his uptick in playing time points to even more opportunities to produce. Leave him in your starting lineup against the Colts.
Kendall Wright/Tajae Sharpe, WRs -- SIT: Neither Wright nor Sharpe are consistent enough to use in fantasy lineups.
Andrew Luck, QB -- START: Luck has quietly put together an awesome fantasy campaign and should be fresh coming off a bye. He's a top-10 option at the position, despite the elevated sack risk.
Donte Moncrief, WR -- START: Moncrief has scored in each of his last two games since returning from an early-season injury. He's a huge red-zone presence and is likely to see a few targets around the end zone yet again.
Buffalo Bills at Cincinnati Bengals: 1:00 p.m. ET on FOX
Tyrod Taylor, QB -- START: Tygod leads all quarterbacks in rushing yards with 362 on the year. That kind of ground production from a quarterback supplements whatever he can do through the air and provides an extremely safe floor. Seeing Taylor produce against Seattle, in Seattle, before Buffalo's bye only makes his outlook that much more promising against a struggling Bengals defense.
LeSean McCoy, RB -- START: McCoy should be back to 100 percent with a week off to rest. Before his hamstring injury he was one of the most productive runners in fantasy, and should have no issues finding room to run against Cincinnati.
Percy Harvin, WR -- SIT: We don't trust Harvin as a fantasy asset just yet. Leave him on the waiver wire for now, but keep an eye on his involvement on Sunday. He could become a solid pickup if he begins producing.
A.J. Green, WR -- START: Green has been the focal point of the Benagls offense this season, with a ridiculous 32 percent share of the team's targets. He's on pace for a career-high in receiving yards and is an every-week starter no matter what the matchup.
Tyler Eifert, TE -- START: Eifert was just a few yards shy of a huge game last week, as he was tackled on a big play before he reached the end zone. He's posted at least 95 yards in two of his last three games since returning from injury and is a weekly TE1.
Giovani Bernard, RB -- FLEX: Bernard is somewhat game-script dependent but is always a threat to bust a couple of big plays. He's more valuable in PPR formats but is worth flexing in standard, too. Again, Buffalo has allowed 10 rushing touchdowns this season, so it's not out of the question for both Hill and Gio to find the paint.
Tampa Bay Buccaneers at Kansas City Chiefs: 1:00 p.m. ET on FOX
Doug Martin, RB -- FLEX: It's not the greatest matchup on paper, but expect Martin to see plenty of volume now that he's gotten a game under his belt after returning from injury.
Adam Humphries, WR -- SIT: Humphries makes this list as Tampa's No. 2 receiver. But there's no strong case for starting him if you have other options. Which you probably do.
Cameron Brate, TE -- START: Brate is a red-zone gem, leading the team in red-zone receptions this season while being tied for the lead in targets and touchdowns in that space as well.
Alex Smith, QB -- START: Yeah, we know Smith has failed to take advantage of a good matchup previously. All we can do is set 'em up and hope that eventually he can knock one down.
Spencer Ware, RB -- START: The Bucs give up a lot of receiving yards to running backs. Good thing Ware can catch the ball.
Jeremy Maclin, WR -- SIT: His recovery from a groin injury might keep him off the field, but nothing about his usage this season suggests he's worth a start even this week.
Travis Kelce, TE -- START: Why wouldn't you start Kansas City's leading pass-catcher against a defense that has been pretty malleable against tight ends? We await your answer.
Chicago Bears at New York Giants: 1:00 p.m. ET on FOX
Eddie Royal, WR -- SIT: You may not have noticed, but Royal played last week for the first time since Week 6. If you trust starting him, you're braver than us. Or you're a wizard.
Rashad Jennings, RB -- SIT: Last week was Jennings' biggest outburst since Week 1. Do you really trust him to do it again versus the fourth-toughest defense for fantasy running backs?
Sterling Shepard, WR -- FLEX: Chicago has allowed the fourth-most receptions to wide receivers over the past four weeks. Hey ... Shepard plays wide receiver. We might be on to something here.
Arizona Cardinals at Minnesota Vikings: 1:00 p.m. ET on FOX
Carson Palmer, QB -- SIT: Last year, you could believe in Palmer to succeed regardless of the defensive matchup. This isn't last year.
John Brown, WR -- SIT: Brown is a boom-or-bust player who's been more bust than boom this season. This matchup doesn't offer a lot of optimism.
J.J. Nelson, WR -- SIT: An elevation to being the team's No. 3 receiver didn't do much to improve his play on the field.
Michael Floyd, WR -- SIT: Just when you thought it was safe to give up on Floyd, he produced. Actually ... it's probably still safe to give up on him.
Cardinals D/ST -- START: Yes. Yes you should start one of the league's best defenses against one of its most underwhelming offenses.
Sam Bradford, QB -- SIT: Bradford has yet to post a 20-point fantasy game this season. This week won't be his first.
Matt Asiata, RB -- SIT: Asiata might be the best option since he's the team's goal-line back. But "best" is relative. Like "tasty" pumpkin pie.
Jerick McKinnon, RB -- SIT: A struggling running back against a stout run defense is not a combination that's going to lead to a lot of fantasy wins.
Vikings D/ST -- START: The Vikes aren't the same unit that they were early in the season. But the Cards aren't the same offense as they were last season.
Miami Dolphins at Los Angeles Rams: 4:05 p.m. ET on FOX
Jay Ajayi, RB -- START: Even though he's running itno the teeth of one of the league's elite defensive lines, Ajayi and his 25.5 touches per game over the last four games cannot be relegated to the bench.
Jarvis Landry, WR -- FLEX (PPR): Landry isn't the locked-in play he was to start the year, as the team now has an actual ground game and doesn't need to manufacture one with quick passes. However, the LSU product is still Tannehill's security blanket and bounced-back with six catches last week.
Dolphins D/ST -- START: An improving defense facing a quarterback in his first career start? Yes please!
Jared Goff, QB -- SIT: Just because he's making his first career NFL start does not mean he should also get his first fantasy start.
Todd Gurley, RB -- START: Will Goff's ascendance open things up for Gurley more? Here's to hoping the big-armed gunslinger can push the Miami defense out of the box a bit.
Kenny Britt, WR -- FLEX: Britt has been Los Angeles' most consistent receiver, but we've yet to see him play with Goff, so there's more risk than usual here.
Lance Kendricks, TE -- START: Kendricks put up a goose egg last week, but in the three games prior had seen a team-high 29 targets. A tight end is often a young quarterback's best friend, so Kendricks is a fine streaming option.
New England Patriots at San Francisco 49ers: 4:25 p.m. ET on CBS
LeGarrette Blount, RB -- START: Beastly running back against a ghastly run defense. You've gotta like those odds.
Dion Lewis, RB -- START: If Lewis is active, he's worth a start as a Swiss Army knife in a high-powered offense.
Julian Edelman, WR -- START: Last week was a nice fantasy outing for Edelman against a good defense. Look for him to build upon it against a bad defense.
Colin Kaepernick, QB -- START: Kaepernick has posted 18 or more fantasy points in three of his last four games -- including against better defenses than New England's.
Carlos Hyde, RB -- FLEX: Let's pray that last week's 1.4-point fantasy effort was merely a hiccup and that better things are to come this week.
DuJuan Harris, RB -- SIT: With Hyde back last week, Harris' snaps and touches diminished significantly. It's hard to trust that things improve this week.
Quinton Patton, WR -- FLEX: Patton is just behind Kerley when it comes to offensive production. If things go as expected, both could see plenty of second-half targets.
Philadelphia Eagles at Seattle Seahawks: 4:25 p.m. ET on CBS
Russell Wilson, QB -- START: Finally healing up, Wilson is looking like the signal caller who set the world on fire late in 2015. Expect him to keep heating up here.
Seahawks RBs -- FLEX:Christine Michael's release means this backfield now belongs to C.J. Prosise and Thomas Rawls. While Pete Carroll hinted to the media that Rawls could "play considerably" if he makes it through practice OK, Prosise is the safer play here. He proved last week he can handle a feature workload. Both could be flexed, though, given all the injuries to the position across the league.
Doug Baldwin, WR -- START: This isn't chasing the points after Baldwin's three-touchdown outburst last week. Instead, it's recognizing that a quarterback and wide receiver are peaking midseason once again.
Tyler Lockett, WR -- LOW-END FLEX: Lockett is a desperation play, as he remains the team's primary deep threat. He has added appeal in leagues that award points for return yards and scores.
Green Bay Packers at Washington Redskins: 8:30 p.m. ET on NBC
James Starks, RB -- FLEX: In his first game back after knee surgery Starks played 69 percent of the offensive snaps and saw just shy of 70 percent of the Packers backfield opportunities. He could be featured more this week against a Washington front allowing 4.6 yards per carry and the fourth-most rushing touchdowns (11) on the year.
Christine Michael, RB -- SIT: Who knows if he'll even be active this week. He's a great stash off waivers for the stretch run, though.
Packers WRs -- START:Josh Norman spends 61 percent of his snaps covering the offensive right side of the field, but has shadowed a few No. 1 wide receivers in 2016. Here's how it breaks down for the Pack:
Davante Adams, FLEX: Plays 48 percent of his snaps on the left side and should largely avoid Norman. He's a strong start this week.
Jordy Nelson, START: Nelson moves all over the field, but 57.7 percent of his season-long snaps in the slot have come in the last three weeks -- a place Norman rarely travels.
Randall Cobb, FLEX: Cobb played 68 percent of the snaps last week, but didn't appear 100 percent healthy. Hopefully another week gets him closer to full health.
Ty Montgomery, SIT: He's lost his stranglehold on backfield snaps and can't be started in fantasy at this point.
Chris Thompson, RB -- SIT: His playing time and usage is too spotty too trust in fantasy. He played just 34 percent of the snaps last week and lost a fumble.
Jamison Crowder, WR -- START: Crowder leads the team in yards (535) and touchdowns (five) and has emerged as Cousins' favorite target of late (team-high 28 targets over the last three weeks).
Pierre Garcon, WR -- FLEX: Garcon hasn't caught a touchdown since Week 5 (his lone score of the year), but has at least five catches and 50-plus yards in six of nine games giving him a nice PPR floor.
DeSean Jackson, WR -- SIT (injury): If Jackson plays he could be worth a look, as he'd be the primary target on the aforementioned deep passes from Cousins.
Washington TEs -- STARTJordan Reed is a must-start against a Packers defense allowing the fourth-most yards to tight ends. But Vernon Davis could be a sneaky streaming play as well. This stop unit just let the Tennessee tight ends crush them for 10 catches, 133 yards and two touchdowns, so there could be plenty to go around for Reed and Davis.
Houston Texans at Oakland Raiders: 8:30 p.m. ET on ESPN
Lamar Miller, RB -- FLEX: The Oakland run defense has stiffened recently, allowing around four yards per carry the last month, versus 4.7 earlier in the year. Yet, Miller sees the vast majority of the backfield opportunities for Houston and warrants a flex play at worst.
DeAndre Hopkins, WR -- FLEX: Hopkins has notched more than 56 receiving yards just once since Week 2, and has also scored just one touchdown in that span. We won't fault you if you bench him, but on an optimistic note he does own 34.6 percent of the team's targets over the last four games.
C.J. Fiedorowicz, TE -- START: Since Week 4, Fiedorowicz is second on the team in targets (39) and catches (27) but leads the team in receiving yards (298) and receiving touchdowns (three). Don't let last week skew your analysis here. Fiedorowicz is a TE1 in this offense.
Derek Carr, QB -- START: The Houston pass defense is legit, with a season-high passing yardage allowed total of just 255. They are more susceptible on the road though, with a five-to-two road-home split in passing touchdowns allowed over their last three contests at each. Carr is a fine start as this game takes place in Mexico City.
Latavius Murray, RB -- FLEX: Murray is coming off his best game of the season (20 carries, 114 yards, three touchdowns), but that was just the second time he's seen 15-plus carries and the first time he's had 60-plus rushing yards in 2016. Houston allows 4.73 yards per carry over the last month, though, so Murray's worth a flex play at least.
Michael Crabtree, WR -- FLEX: Crabtree draws the tougher cornerback matchup as he's likely to face Jonathan Joseph more often as the corner lines up on the offensive right side of the field 86.3 percent of the time. That could cap Crabtree's big-play and scoring ability (Joseph has not allowed a touchdown since Week 2 of 2015).
New Orleans Saints at Carolina Panthers: 8:25 p.m. on NBC, NFL Network and Twitter (Thursday)
Kelvin Benjamin, WR -- START: It's been since Week 3 that Benjamin has failed to record 70 yards and/or a touchdown in a game. He has target totals of 12, seven, five and 14 over his last four games. This is an ideal spot for him.
Greg Olsen, TE -- START: The stud tight end has come in under 40 yards receiving in two of his last three games. This is a great spot for him to completely blow up, as he had been doing prior to this quiet stretch.