Polamalu sprained a knee and Holmes injured ankle ligaments during a 19-16 overtime loss Sunday, one of the NFL's biggest upsets this season. Both are listed as doubtful for Monday night's home game against Miami (0-10).
Although coach Mike Tomlin wouldn't list either player as out, he talked Tuesday as if neither would play. Both injuries are the type that can sideline players for multiple games.
Tomlin called them "two significant injuries."
Holmes has a sprain in his upper right ankle, or injured ligaments between the two major bones of the lower leg at ankle level. While Holmes' sprain is mild, the injury is typically much worse than a regular sprain and can keep a player out for three to four weeks.
Holmes, a first-round draft pick in 2006, leads the division-leading Steelers (7-3) in receptions (39), touchdown catches (7) and average gain per catch (17 yards).
Tomlin wouldn't choose a replacement starter for Holmes, saying Nate Washington, Cedrick Wilson and possibly Willie Reid would divide playing time. Washington had two TD catches Nov. 5 against Baltimore and is the only Steelers wide receiver other than starters Holmes and Hines Ward with a touchdown reception.
Tyrone Carter will start for Polamalu, and cornerback Deshea Townsend can also play safety if needed, Tomlin said.
"It's going to require multiple people to step up and fill the roles they provide for us, which is great," Tomlin said. "This is a team, and it's the ultimate team game. We're looking forward to these guys stepping up and delivering for us."
While Polamalu is having a down season statistically, with no interceptions or sacks and one fumble recovery, his ability to shift positions from play to play is an important element of Pittsburgh's league-leading defense.
Opposing coaches talk constantly of adjusting to Polamalu, who may line up as a pass-rushing linebacker on one play or in deep zone coverage on the next. Despite Sunday's loss, the Steelers are allowing an average of 40 fewer yards per game than any other team.
"I don't want our level of preparation this week to be a response to last week's performance," Tomlin said. "I want it to be because we have a football game to play. That's the only way we're going to be great, is that we understand all of these games are equally weighted, and every time you take the field you've got to come to play. That's what great teams do."
The offensive line wasn't the only culprit in Roethlisberger's seven sacks, according to Tomlin, who said the quarterback must get rid of the ball sooner at times.
"It's not a five-man job in terms of protecting our quarterback, it's a unit's job," Tomlin said. "We need to do a better job of getting open. We need to do a better job of protecting up front. We need to do a better job of protecting at the running back's position. We have to do a better job of deciphering what we're looking at and getting the ball out of our hands."
The Steelers won't do anything specific this week to address their road problems -- they are 5-0 at home and 2-3 on the road -- because their next two games are at home.
"As a coach, your level of expectation is they are wired and ready to play on a weekly basis," Tomlin said. "That's what this business is about. The reality is sometimes that's not the case. Their play is usually an indication of that."
Copyright 2007 by The Associated Press