"He didn't feel good," Whisenhunt said of Kolb. "He exhibited some (concussion) symptoms. Our doctors right now, if it's even close they're going to err on the side of caution. ... We didn't feel like it was the smart thing to do so we stuck with John."
Kolb, who was initially listed as questionable to return, was injured when he was hit as he tried to throw on a third-down play. He fumbled, but the Cardinals recovered. He was replaced by Skelton, who threw three interceptions and was benched after three quarters in Arizona's 23-7 loss at San Francisco on Nov. 20.
The Cardinals announced linebacker Paris Lenon was questionable to return to the game with a left knee injury.
The Associated Press contributed to this report.