Wells' playing status will be a game-time decision. He sat out practice on Friday, but stated on Thursday that his knee is "a lot better."
"Like I said, we do have three (other) backs we feel good about," coach Ken Whisenhunt said. "So even if he is in a spot role, that is something I think Beanie could do. As far as starting, I'd have concerns about that, but getting in for a couple carries here and there or just contributing, that's not as big of a factor with where he has been."
Even if Wells is available, the second-year back remains listed behind starter Tim Hightower on the depth chart.
Wells, a first-round draft pick out of Ohio State, led the Cardinals in rushing last season with 793 yards in 176 carries, an average of 4.5 yards per carry. Hightower enters his third NFL season after being picked in the fifth round out of Richmond.
The burly Hightower carried 143 times for 598 yards (4.2 yards per carry) and caught 63 passes -- second-most among NFL running backs, behind Baltimore's Ray Rice -- for 428 yards.
The Associated Press contributed to this report.