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| Rick Stewart / Getty Images |
| 49ers RB Frank Gore paced the 49ers with 89 yards from scrimmage. |
It was over when ...
The Bills turned the ball over on downs as quarterback J.P. Losman was sacked and threw two incompletions on Buffalo's final possession.
Game ball
Patrick Willis led a stingy 49ers defense with 14 tackles and forced a fumble on Buffalo's opening drive of the second half.
Key stat
The Bills failed to capitalize on four trips inside the red zone. Two misses by kicker Rian Lindell, including a 20-yard attempt in the second quarter, did not help their cause.
Noteworthy
Losman started the second half for the Bills due to a groin injury sustained by starter Trent Edwards. Losman finished 11-of-17 with 93 yards. ... 49ers WR Isaac Bruce's first-quarter touchdown was the 90th of his career. ... San Francisco's win prevented the Arizona Cardinals from clinching the NFC West. ... Bills RB Marshawn Lynch finished with a season-high 134 yards rushing on 16 carries.
