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Colts WR Reggie Wayne recorded his second 100-yard game of the season.

It was over when ...
Ben Roethlisberger's desperation throw into the end zone was bobbled by two players before falling into the arms of Colts safety Melvin Bullitt as time expired, preserving the 24-20 win for Indianapolis. It was Roethlisberger's third interception of the game and eighth in the last three weeks.

Game ball
Peyton Manning threw for 240 yards and three touchdowns against a pass defense that ranked first in the league coming in and had only allowed opponents 164 yards per game through the air. Manning has two TD passes in each of his last three games.

Key stat
The Colts converted the first two Roethilisberger misfires, both in Steelers territory, into 14 points.

Noteworthy
The Colts are 2-12 all-time in Pittsburgh and won for the first time in 12 tries. Their last win came in 1968. ... Colts WR Marvin Harrison took a shot when he was sandwiched between two Steelers defenders on the opening drive of the second half and had to leave the game. He returned on the next series. ... The Steelers are 5-1 vs. the AFC this season.