Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 2 fantasy matchups.
Seattle Seahawks at Los Angeles Rams: 4:05 p.m. ET on FOX
Christine Michael, RB -- SIT: Keep Michael on your roster in the event that Rawls doesn't regain 2015 form or gets hurt again. However, His Wokeness is no longer a fantasy play.
Tavon Austin, WR - SIT: After collecting 13 yards on 12 targets in Week 1, it's impossible to play him with confidence.
Tampa Bay Buccaneers at Arizona Cardinals: 4:05 p.m. ET on FOX
Doug Martin, RB -- FLEX: His ceiling might not be high in this contest, but he's still worth playing with expectations kept in check.
Charles Sims, RB -- FLEX: Once again Sims was a big part of the game plan. In a potential shootout like this, he's worth chasing for passing work.
Austin Seferian-Jenkins, TE -- SIT: He scored in Week 1 but didn't even play half the snaps. Approach with caution.
Carson Palmer, QB -- START:Even in a game where he didn't play well, Palmer cracked 18 fantasy points. The Tampa Bay secondary is especially leaky.
Michael Floyd, WR -- FLEX:Floyd is in a nice bounce back spot in wake of a slow debut where he struggled to get open routinely.
Jacksonville Jaguars at San Diego Chargers: 4:25 p.m. ET on CBS
Allen Hurns, WR -- FLEX: There is certainly a chance that this game turns into a shootout, which means more targets headed in Hurns' direction.
Philip Rivers, QB -- SIT: With his best pass-catching weapon sidelined for the season, we could see a decrease in pass attempts. It's a scary thought against an improved defense.
Antonio Gates, TE -- START: The ageless wonder will once again shoulder a large load in the passing game against a unit that has traditionally struggled to cover the position.
Atlanta Falcons at Oakland Raiders: 4:25 p.m. ET on CBS
Devonta Freeman, RB -- FLEX: The newly-minted committee in Atlanta won't please Freeman owners, but there could still be an opportunity to produce.
Mohamed Sanu, WR -- START: Sanu played very well last week and deserves to be in your lineup against Oakland this week.
Amari Cooper, WR -- START: Cooper's 137-yard outing looks like the start of a big season. If he can find the end zone against Atlanta, he'll really be off and running.
Michael Crabtree, WR -- START: There is enough volume in the Oakland passing game that both wideouts should be able to produce for fantasy enthusiasts.
Indianapolis Colts at Denver Broncos: 4:25 p.m. ET on CBS
Andrew Luck, QB -- START: Yes, the Denver defense is scary, but no, you're not benching Luck. His talented group of pass-catchers combined with his rushing ability will help him maintain a safe fantasy floor.
Frank Gore, RB -- SIT: Gore is running behind a shaky offensive line facing one of the game's elite defenses. He could sneak in a goal-line touchdown, but there are likely better options on most fantasy rosters than Gore.
T.Y. Hilton & Donte Moncrief, WRs -- FLEX: Hilton had a solid outing last year against Denver (five catches, 82 yards), while Moncrief disappointed (three catches, 30 yards). That's in the past, though, and this is now. The Colts passing attack has too much firepower to completely bench, even in a tough matchup.
Dwayne Allen, TE -- START: The tight end position was a fantasy wasteland in Week 1. It's foolish to bench a player like Allen attached a high-octane passing offense who is coming off seeing roughly 13 percent of the team targets. Allen's a low-end TE1 this week.
Trevor Siemian, QB -- START (2QB): Last week, the Colts let Matthew Stafford move up and down the field with short-range passes. Siemian averaged a meager 5.6 yards per aimed throw (slightly higher than Stafford). Even if Demaryius Thomas sits or is limited (hip injury), Siemian could be worth a start in 2QB formats of daily fantasy.
Demaryius Thomas, WR -- FLEX (INJURY): Thomas would be a fine start, but a hip injury suffered in the first quarter last week has been limiting him in practice. Monitor his health leading up to Sunday, because while the team expects him to play, injuries like this can linger and flare up at any time.
Emmanuel Sanders, WR -- START: Sanders is almost a must-start this week, especially with Thomas less than 100 percent. The Colts secondary is in shambles after allowing Matthew Stafford to complete nearly 80 percent of his passes for 340 yards and three touchdowns. Even if Sanders doesn't go deep much with Siemian under center, he should see plenty of targets and will be a solid start.
Green Bay Packers at Minnesota Vikings: 8:30 p.m. ET on NBC
Aaron Rodgers, QB -- START: It's not crazy to sit Rodgers this week if you for some reason have another strong quarterback in a great matchup on your roster (Eli Manning, Drew Brees, etc). However, despite Rodgers throws on average 40 yards and .5 touchdowns less per game against Mike Zimmer-led defenses in his illustrious career, his ever-present sky-high fantasy ceiling is worth chasing.
Jordy Nelson, WR -- START: It was great seeing Nelson get back on track with a touchdown catch in Week 1, but he's not quite 100 percent, as evidenced by his 5.3 yards per reception, which was nearly 10 yards lower than his career average (15.27) prior to 2016. Still, he's the lynchpin to this passing attack, and is a must-start.
Vikings starting QB -- SIT: Mike Zimmer isn't naming a starting quarterback until Sunday. You don't need to wait that long to name your fantasy starter. Literally pick any other quarterback in the NFL.
Adrian Peterson, RB -- FLEX: Peterson's putrid Week 1 performance (19 attempts, 31 yards, 1.63 ypc) has plenty of fantasy owners panicking, and the Week 2 matchup isn't much better. The Packers stuffed T.J. Yeldon last week, holding him to 1.86 yards per carry on 21 attemps. Peterson is the primary driver of the Minnesota offense though, and is worth flex consideration on volume alone.
Stefon Diggs, WR -- FLEX: Diggs' breakout season got off to a great start in Week 1 as he saw over 27 percent of the team target and notched a stellar 11.4 yards per target. While Green Bay boasts a talented young secondary, Diggs is a decent option in standard and PPR formats as the No. 1 wide receiver in Minnesota.
Kyle Rudolph, TE -- START: Rudolph saw the second-most targets on the team in Week 1 (eight), and is facing a Packers defense that allowed Julius Thomas and Marcedes Lewis to rack up a combined 112 yards and a touchdown on seven targets. Given the disaster the tight end position produced last week, Rudolph warrants a start.
Philadelphia Eagles at Chicago Bears: 8:30 p.m. ET on ESPN
Carson Wentz, QB -- START (2QB): Yes, Wentz whomped the Browns last week, but his performance was encouraging, especially as he completed five of his six attempts of 15-plus yards downfield. Brock Osweiler found success against this Bears defense last week, so those in deeper or 2QB formats should feel OK about trotting out Wentz.
Ryan Mathews, RB -- START: Mathews is the featured back in this offense, and so far has a stranglehold on red-zone touches (saw 100 percent of the carries, and 78 percent of all opportunities). Lamar Miller did work against the Bears front seven last week, so Mathews should find at least enough space to put up RB2 numbers.
Jordan Matthews, WR -- START: While we thought Matthews was pigeon-holed as a slot receiver, he appears to be spreading his wings under Doug Pederson, as he played more snaps outside (36) than in the slot (31) in Week 1. Matthews' new-found versatility as the No. 1 receiver for Wentz makes him a nice start against a banged up Chicago secondary.
Jay Cutler, QB -- SIT: Despite being down for much of his Week 1 game, Cutler still threw the fourth-fewest passes in the NFL in Week 1 (29, tied with Ryan Tannehill). He lacks the volume and weapons to be a weekly starter in fantasy.
Jeremy Langford, RB -- START: While Langford continued his inefficient ways from last season (3.6 yards per carry in Week 1), he saw 87.5 percent of the backfield opportunities (targets and carries), and scored a touchdown. Even if he plods along like that each week, he'll be fantasy relevant on volume alone.
Alshon Jeffery, WR -- START: Jeffery got off to a hot start in Week 1 with 105 yards in the first half, but was blanked in the second (he only saw two targets after half time). Still, he's the top option in this offense and if things go bad for Cutler, we know he's always looking for Jeffery.
Kevin White, WR -- SIT: White's "rookie" debut was uninspiring, as he caught just three of a team-high seven targets for 34 yards and caused an interception with a bad route. Until he starts putting it together on the field, he shouldn't have a spot in fantasy lineups.
Zach Miller, TE -- SIT: We'd hoped Miller's strong finish to the 2015 campaign would carry over into 2015, but four targets in Week 1 have us a bit worried. He could bounce-back soon, but let him sit on the bench and stream the position until Miller catches fire again.
Completed Week 2 games
New York Jets at Buffalo Bills: 8:25 p.m. ET on NFL Network, CBS and Twitter
Eric Decker, WR -- START: This dude is a touchdown machine. He started the season with one last week, and there's no reason he can't keep rolling against a decimated Buffalo defense on Thursday night.
Sammy Watkins, WR -- SIT: Steer clear of this situation at all costs. Watkins' status (foot) will come down to a game-time decision and that's never a good sign. Even if he does play, it's hard to believe he will be much more than a decoy.
San Francisco 49ers at Carolina Panthers: 1:00 p.m. ET on FOX
Torrey Smith, WR -- FLEX: Smith's value could come late as the Niners throw the ball in an attempt to catch up.
Jeremy Kerley, WR -- FLEX: After getting a team-high 11 targets in Week 1, it looks like Kerley could be a bigger part of the passing game than expected. But don't get crazy.
Cam Newton, QB -- START: Even against arguably the best defense in the league, Newton found a way to score 21 fantasy points. The Niners don't portend to offer that level of resistance.
Jonathan Stewart, RB -- START: Stewart dominates the running back carries in the offense, but he'll still occasionally lose out to Carolina's dynamic quarterback in scoring situations.
Kelvin Benjamin, WR -- START: Last week's 16-point performance was a reminder to all who doubted Benjamin this summer. There's more where that came from.
Panthers D/ST -- START: They might have allowed 21 points last week, but this group still gets after the quarterback and forces turnovers. Sit 'em at your own peril.
Dallas Cowboys at Washington Redskins: 1:00 p.m. ET on FOX
Jason Witten, TE -- START: Witten is worth a start after seeing 31.1 percent of the team targets in Week 1. Young passers often lean on tight ends as security blankets, giving Witten an added boost in PPR formats.
Cole Beasley, WR -- SIT: Beasley is worth a look in deeper PPR formats, but fantasy owners can likely find better production elsewhere.
Kirk Cousins, QB -- SIT: Cousins was scattershot in Week 1, despite playing with a loaded pass-catching corps. With Dallas likely slowling the game down again (36:43 time of possession in Week 1) to protect their leaky defense and rookie quarterback, Cousins will have even fewer chances to score. He's a sit this week.
Chris Thompson, RB -- LOW-END FLEX (PPR): Even though Thompson only saw one more target than Jones in Week 1, he's the more dynamic pass-taching option. He'll see a few carries as well, helping his weekly floor. He's not an exciting option right now, but he's there if you need him.
DeSean Jackson, WR -- START: Jackson looked strong in the season debut, stretching the field and seeing work in the intermediate areas as well. He's an excellent WR2-3 or flex play given his big-play nature, and his floor in this offense feels safer than in years past.
Jordan Reed, TE -- START: Reed is a mismatch at tight end and one of Cousins' favorite targets (team-high 11 looks in Week 1). Even though he disappointed a bit out of the gate, he needs to be started on a weekly basis.
Cincinnati Bengals at Pittsburgh Steelers: 1:00 p.m. ET on CBS
A.J. Green, WR -- START: Green had 12 catches for 180 yards and a score last week. Dalton has tunnel vision for his best wideout and fantasy owners will reap the rewards.
Jeremy Hill, RB -- LOW-END FLEX: As was the case last year, Hill's fantasy value still seems very touchdown dependent. He fell into the end zone last week, but if you flex him, just realize his floor is basement-level if he doesn't score.
Jesse James, TE -- SIT: If you're absolutely desperate for a tight end, James has a decent floor. But that's only if you're desperate, which you shouldn't be yet since it's only Week 2.
New Orleans Saints at New York Giants: 1:00 p.m. ET on FOX
Drew Brees, QB -- START: Last season in this matchup, Brees went for seven touchdowns. That seems unlikely, but he should still be pretty productive.
Odell Beckham, Jr., WR -- START: Only OBJ could cause a freakout by scoring "just" 7.30 fantasy points. You're starting him this week. You know it and we know it, and you know we know it.
Shane Vereen, RB -- FLEX: This is mostly for the PPR crowd, but Vereen should see a healthy number of targets again this week.
Miami Dolphins at New England Patriots: 1:00 p.m. ET on CBS
Ryan Tannehill, QB -- SIT: On the road against New England is not a spot to start an average fantasy quarterback, especially when he has limited cupboard of pass-catchers to work with.
Arian Foster, RB -- START: Foster is another player that you probably want to make best use of while he's healthy. He's the clear feature back after playing on 87 percent of the Dolphins' snaps in Week 1. He has a defined role as a passing-down back, as well, and the Dolphins figure to be trailing against a still solid New England scoring unit.
Jarvis Landry, WR -- FLEX: As per usual, Landry led the team in targets but failed to crack 60 yards on seven receptions in Week 1. New England will likely look to limit big play options in Miami's offense and be content to cede short throws to Landry, much like they were with Larry Fitzgerald last week.
Kenny Stills, WR -- SIT: He's the clear No. 2 receiver in this passing game but still doesn't merit fantasy consideration in a matchup like this.
LeGarrette Blount, RB -- START: Despite his mediocre reputation, Blount is completely fantasy viable in games where New England is expected to win. This week fits that mold and Blount was a workhorse back in Week 1 handling over 20 carries.
Martellus Bennett, TE -- SIT: Even if Gronk sits again, Bennett is a risky fantasy play. He started in place of the All-Pro last week but was often left in to block in wake of a number of tackle injuries in New England.
Kansas City Chiefs at Houston Texans: 1:00 p.m. ET on CBS
Spencer Ware -- START: Ware raked as a pass-catcher last week with 129 receiving yards as the Chiefs were climbing out of a 21-point hole in the second half. He added 70 rush yards and a touchdown to finish as the RB3 overall for Week 1. He should shoulder a heavy workload again versus Houston, so lock him in as an RB1.
Travis Kelce, TE -- START:Kelce is good for about 60 to 70 yards on a weekly basis and if he gets into the end zone, he's a top-10 tight end. He needs to be started given the lack of other talented pass catchers in Kansas City.
Brock Osweiler, QB -- SIT:Osweiler was a decent streaming option in Week 1 if you needed help, but we're not ready to anoint him as a weekly play just yet. Let him fester on the waiver wire for now.
Lamar Miller, RB -- START:Lamar Miller is going to eat against a depleted Kansas City linebacker unit that is without Justin Houston, Josh Mauaga and is using Tamba Hali on limited snaps. Miller logged 32 touches in Week 1 and it's obvious that the Texans are going to feed him a huge workload. He's a locked-in RB1.
DeAndre Hopkins, WR -- START: Despite having a legitimate receiving option on the opposite side of the field (Will Fuller), Hopkins remains a weekly must-start no matter what the matchup. He'll be peppered with targets all year, especially in the red zone.
Will Fuller, WR -- FLEX:In his rookie debut, Fuller led Houston in targets and collected over 100 yards and a touchdown. We'd like to see him do it again before we call him a weekly starter, but you're safe plugging him in as a flex this week.
Tennessee Titans at Detroit Lions: 1:00 p.m. ET on CBS
DeMarco Murray, RB -- FLEX: If you have Murray you want to make use of him while he's still the clear-cut starter. Nothing about this spot screams that he's a great play, but running back options are slim.
Baltimore Ravens at Cleveland Browns: 1:00 p.m. ET on CBS
Mike Wallace, WR -- FLEX:Wallace might be the only trustworthy wideout in Baltimore from a fantasy perspective. He flashed his big-play ability a week ago, and odds are he'll be able to get behind Cleveland's secondary for another trip to the end zone in Week 2.
Isaiah Crowell, RB -- FLEX: Crowell's weekly upside is capped buy his limited volume as a runner. It's hard to imagine him logging 15 or more carries, but he did manage to score on just 11 attempts last week, so it's not out of the question.