In his first start since fracturing his ribs in a preseason game, Newton threw for 281 yards and a touchdown and ran for 19 yards on four carries, He helped the Panthers improve to 2-0 for the first time since 2008 and grab sole possession of first place in the NFC South.
Newton shook off a slow start and completed 22 of 34 passes and overcame five sacks.
"I felt like I was getting antsy early on and that comes from a lack of playing time," Newton said. "... I was getting my feet back under me and as the game went on I started feeling more comfortable and it showed."
Wearing a thick flak jacket, it took a while for Newton to find his stride.
He scrambled from the pocket on one second-quarter run and dived headfirst instead of sliding. It was similar to the play against New England on Aug. 22 that left him with cracked ribs and sidelined him for the season opener against Tampa Bay.
Later in the fourth quarter Newton ran again, turning the corner inside the 5 and diving toward the pylon.
Earlier in the day Rivera made a difficult decision to deactivate Pro Bowl defensive end Greg Hardy, saying that the NFL "culture has changed" and the team needed to make the right decision. The decision came one day after the Minnesota Vikings announced they would deactivate Adrian Peterson, who was indicted on child abuse charges on Saturday.
Hardy was convicted July 15 on two counts of domestic violence and Rivera didn't think it was right to allow him to play given the events of the week.
Carolina's defense didn't seem to miss a beat.
The Panthers had three takeaways, four sacks and held the Lions scoreless in the first half one week after Matthew Stafford and company put up 35 points against the Giants. Mario Addison helped fill the void left by Hardy with 2 ½ sacks, and cornerback Antoine Cason had 10 tackles, two forced fumbles and a recovery.
But the lead was short-lived.
Thomas DeCoud tipped a deep ball from Stafford and Melvin White intercepted to set up Carolina's next score. Rookie wide receiver Kelvin Benjamin, who struggled with dropped balls all day, hauled in a one-handed grab along the left sideline. Jonathan Stewart capped the drive with a 2-yard run and Newton threw to Jerricho Cotchery for a 2-point conversion to put Carolina up 21-7.
"When you don't take advantage of your opportunities you miss chances and turn the ball over, you're not going to have a good day," Stafford said.
NOTES: Newton apologized to Lions defensive tackle Ndamukong Suh after the game, saying he didn't mean anything offensive earlier in the week when he referred to him as "Donkey Kong Suh." ... Caldwell said he "won't make any rash decisions" on whether to keep Freese as the kicker after his two misses. ... Lions cornerback Nevin Lawson was carted off the field with a foot injury and did not return.
Copyright 2014 by The Associated Press