NFL.com analysts provide one bold prediction for Week 5 of the 2025 NFL season, from fantasy forecasts to team-based takes.
Drake Maye leads the Patriots to a prime-time upset of the Bills.
The NFL’s current leader in completion rate -- Maye's at a pristine 74 percent through four games -- faces a tough test in the division-rival Bills on Sunday night. Not only will he pass the test -- the second-year pro will complete 30+ passes for 300+ yards and 3+ touchdowns in a 30+ point fantasy day. Oh, and the Pats will earn their third win of the season.
Tough sledding for Jalen Hurts and Bo Nix in a defensive stalemate.
Sunday's Broncos-Eagles matchup features two defenses on opposite ends of the spectrum when it comes to sacks. Led by edge rushers Nik Bonitto and Jonathon Cooper, Denver leads the NFL in the category with 15, while the Eagles entered this week tied for 26th with just five. Both units get after it in Week 5 to combine for a whopping 10 sacks in a low-scoring affair in Philly.
Both Lions RBs feast for the second time this season.
The easiest analysis here would be to say “Bengals.” But since I have to hit a certain word count, I’ll expand. The Bengals' run defense ranks in the bottom seven of the league and they saw the fifth-most rushing attempts in September. Detroit is one of the run-heaviest offenses in the league. Leading with the run against this defense should yield big days for Jahmyr Gibbs and David Montgomery, who'll each score 25-plus fantasy points.
Stefon Diggs makes a splash in his return to Buffalo.
As a player, Patriots head coach Mike Vrabel was 16-2 versus the Bills. He brings that magic -- with the help of a Stefon Diggs revenge game -- to Buffalo on Sunday night, serving up an upset of the undefeated Bills. Drake Maye earns a signature victory, outdueling Josh Allen, while Diggs torches his former team for two touchdowns.
Dolphins RB racks up 40(!) fantasy points.
De'Von Achane is one of the most explosive running backs in the NFL. This week, he faces the Panthers, who rank 23rd in the NFL against the run and are allowing over 5 yards per carry to running backs this season. With the game script on his side, Achane explodes for 40 fantasy points.
