Coach Sean McDermott confirmed McCoy is in the concussion protocol after the game.
McCoy was injured after he was hit out of bounds on a 1-yard run on Buffalo's opening drive. He was on the ground briefly before walking into the sideline medical tent under his own power. He was then accompanied by a trainer to the Bills' locker room.
McCoy has been the subject of trade speculation in recent weeks ahead of the Oct. 30 trade deadline. While the Philadelphia Eagles are among the teams that have expressed interest in McCoy, NFL Network Insider Ian Rapoport reported last week there's a good chance the running back remains with the team in 2019.