Vikings coach Mike Zimmer took issue with the lack of holding penalties called against the 49ers on Sunday. San Francisco tight end George Kittle took issue with Zimmer.

Michael F. Florio breaks down the top fantasy football matchups for Week 12 of the 2021 NFL season.

The 49ers announced a slew of moves ahead of Sunday's rematch with the Cardinals. Chief among them was the return of a certain star TE.

Michael F. Florio breaks down the top fantasy football matchups for Week 9 of the 2021 NFL season.

As George Kittle returned to practice this week after a stint on injured reserve due to a calf injury, questions turned to whether the 49ers are overworking their star tight end. Kittle has played just 12 of the past 23 games due to injury.

San Francisco 49ers tight end George Kittle (calf) will miss at least three games after being placed on injured reserve, NFL Network's Tom Pelissero reports.

NFL.com's Michael F. Florio breaks down the best and toughest fantasy matchups for Week 5 of the 2021 NFL season.

Niners head coach Kyle Shanahan said quarterback Jimmy Garoppolo will miss practice Wednesday, but still left the door open for him to play Sunday against the Cardinals. 

Niners coach Kyle Shanahan told reporters Monday that Jimmy Garoppolo's calf injury looks to be a contusion, will be revaluated Wednesday and the veteran QB has a chance to play Sunday against the first-place Arizona Cardinals. LT Trent Williams (shoulder) is day-to-day and also has a chance to play. 

Baltimore Ravens quarterback Lamar Jackson is listed as questionable with a back injury, but should be good to go Sunday against the Denver Broncos, a source tells NFL Network Insider Ian Rapoport.

Michael F. Florio breaks down the top fantasy football matchups for Week 3 of the 2021 NFL season.

In the NFC, the West has been a cauldron of battle for years, with different winners the past three seasons and all four teams winning at least once since 2015. George Kittle sees San Francisco as a notable contender.

Analytics guru Cynthia Frelund reveals her projected win total for each NFC team, forecasting the West to produce three playoff participants. So, who's the odd team out?

It's that time of year again, when NFL players cast their votes to identify the best in the league heading into the 2021 NFL season.

The 2017 NFL Draft class is absolutely loaded with talent, but only one player can be crowned the best of the bunch. Who holds that coveted spot in Brian Baldinger's list of the top 10 players of the 2017 class heading into 2021?

It's that time of year again, when NFL players cast their votes to identify the best in the league heading into the 2021 NFL season. 

With the 2021 NFL season right around the corner, Nick Shook decided to take a step back and put together a list of the league's greatest highlight makers. Check out the 32 most thrilling talents of today ... and tomorrow.

Will Matthew Stafford deliver for the Rams? Can a healthy Nick Bosa get the 49ers back on track? Adam Maya provides a training camp preview for the NFC West, with position battles and key players to watch across all four rosters.

Will CeeDee Lamb take a massive leap in his second season? Is Tom Brady set to defy Father Time yet again? Can George Kittle bounce back from injury in a big way? Dan Hanzus predicts each NFC team's MVP for the 2021 season.

After an injury-riddled 2020 season, the San Francisco 49ers are back with a roster that appears loaded on paper. Can Kyle Shanahan get them back to the Super Bowl? Adam Rank examines the state of the franchise ahead of the 2021 campaign.

Joining NFL Network's "Good Morning Football" Tuesday, George Kittle gushed over the No. 3 overall pick Trey Lance. 

What is the best possible team money could buy in 2021? NFL Media researcher Anthony Holzman-Escareno builds the ultimate 53-man roster while remaining under this year's $182.5 million salary cap.

Since divisional realignment back in 2002, we've only experienced two NFL seasons in which at least one team didn't go from worst to first. Who could accomplish the feat in 2021? Adam Schein ranks the eight candidates.

Poring over all 32 NFL teams, Adam Rank identifies one player to root for on each roster in 2021. Why does Dak Prescott have his support? Which rookies made the list?

What would the NFL's richest roster look like? Anthony Holzman-Escareno assembles an all-star collection of the highest-paid players at each position heading into the 2021 season.

NFL analyst Brian Baldinger breaks down the performance of the San Francisco 49ers offense during the Week 12 win over the Minnesota Vikings.

NFL Network's Cynthia Frelund's score and stat projections for notable Week 12 games.

San Francisco 49ers quarterback Jimmy Garoppolo slings pass to tight end George Kittle on fourth-and-goal TD.

NFL analyst Brian Baldinger loves what he sees from the San Francisco 49ers in the Week 10 win over the Los Angeles Rams.

See the highest graded players according to Pro Football Focus from Week 10 of the NFL season

San Francisco 49ers quarterback Jimmy Garoppolo throws a touchdown pass to tight end George Kittle that caps an 18-play drive.

Watch Manning bros react to the San Francisco 49ers' 18-play drive resulting in a TD to tight end George Kittle.

Watch the San Francisco 49ers' best plays through the first 9 weeks of the 2021 season.

The "NFL Slimetime" team goes head-to-head against Marsai Martin in Week 10 fantasy.

Watch every San Fransisco 49ers tight end George Kittle catch from his return to action in the Week 9 matchup against the Arizona Cardinals.

Can't-Miss Play: San Fransisco 49ers tight end George Kittle makes a one-handed catch in heavy traffic.

Can't-Miss Play: San Fransisco 49ers tight end George Kittle's insane adjustment nets 29-yard grab on sideline.

San Fransisco 49ers tight end George Kittle high-points quarterback Jimmy Garoppolo 6-yard touchdown pass.

San Fransisco 49ers tight end George Kittle's first catch since return goes for 19 yards.

Watch some of San Francisco 49ers tight end George Kittle's best mic'd up moments on National Tight Ends Day.

San Francisco 49ers tight end George Kittle explains the origins of National Tight End Day.

"NFL Slimetime" host George Johnston previews National Tight End Day on October 24.

Mike Yam reports that George Kittle has been placed on injured reserve with a calf injury.

Watch the San Francisco 49ers best plays from the first four weeks of the 2021 season.

NFL Network's Cynthia Frelund shares which 2-2 teams are contenders or pretenders.

San Francisco 49ers quarterback Jimmy Garoppolo finds tight end George Kittle for 18-yard gain.

NFL analyst Brian Baldinger breaks down how San Francisco 49ers quarterback Jimmy Garoppolo set up his team for success in Week 3 despite their loss to the Green Bay Packers.

Watch all of the highlights from the Green Bay Packers and San Francisco 49ers from their Week 3 matchup on "Sunday Night Football" in the 2021 NFL regular season.

Clutch Kittle! San Francisco 49ers quarterback Jimmy Garoppolo's third-down throw finds 49ers tight end George Kittle for a HUGE 39-yard catch and run.

NFL Network's Patrick Claybon, Kimmi Chex, Cynthia Frelund and Adam Rank predict the top scorers at each position in Week 3.