Gregg Rosenthal looks at one key homegrown player on each NFC team who could make a BIG difference in 2020. Can Leighton Vander Esch stay healthy? Will Dwayne Haskins make the leap?

Robert Saleh's sideline enthusiasm might attract the cameras, but he's actually quieter than you think he is, Steve Wyche writes. Get to know the architect of the San Francisco 49ers' elite defense.

Kirk Cousins and the Minnesota Vikings travel to Santa Clara to take on Jimmy Garoppolo and the San Francisco 49ers on Saturday. Jeremy Bergman previews the Divisional Round playoff game.

With the regular season in the rearview and the postseason on the horizon, Dan Hanzus takes a look at how all 32 teams stack up. Check out the updated Power Rankings.

With their 26-21 win over the Seattle Seahawks on Sunday night, the San Francisco 49ers clinched their first NFC West title since 2012 and home-field advantage throughout the postseason.

NFL Network's Jim Trotter reports from an instant classic on Monday night in Santa Clara, Ca., where the Seahawks prevailed over the 49ers in OT to hand San Francisco their first defeat.

The Seattle Seahawks (8-2) escaped Levi's Stadium with a nail-biting 27-24 overtime victory over the previously undefeated San Francisco 49ers (8-1) on the legs of Jason Myers.

Jelani Scott previews what to watch for as the Seattle Seahawks and San Francisco 49ers clash in an NFC West bout on "Monday Night Football."

One of San Francisco's big-ticket items on defense is done for the year. Niners starting inside linebacker Kwon Alexander is out for the remainder of the season after suffering a torn pectoral muscle.

The San Francisco 49ers held off a late charge from the Arizona Cardinals to secure a 28-25 win over their NFC West rivals and keep their perfect season alive on "Thursday Night Football."

One of John Lynch's first signings as general manager of the San Francisco 49ers is no longer in their plans. San Francisco is releasing veteran linebacker Malcolm Smith after just two seasons.

The linebacker sprung into action at a 2015 frat party to help a classmate. Her father hasn't forgotten it.

Tip drill! San Francisco 49ers safety Jaquiski Tartt picks off Arizona Cardinals quarterback Kyler Murray's batted ball for a key interception.

San Francisco 49ers STONEWALL Jacob Hollister on final play to seal win.

Watch the best defensive plays from the San Francisco 49ers in the 2019 regular season.

Watch the Seattle Seahawks vs. San Francisco 49ers highlights in Week 10 fo the 2019.

San Francisco 49ers linebacker Dre Greenlaw ends Seahawks' drive with STELLAR red-zone interception.

Watch the San Francisco 49ers vs. Arizona Cardinals highlights from Week 9 of the 2019 season.