Does any pair of teammates top the Chargers' Keenan Allen and Mike Williams among the NFL's best receiver duos? In the latest edition of his Scout's Notebook, Bucky Brooks ranks the top duos at 11 key position groups heading into the 2022 season.

49ers WR Deebo Samuel suffered a groin injury against the Vikings. Plus, other news from around the NFL on Sunday.

Jim Trotter catches up with the 49ers' DeMeco Ryans and some of the people he's made a profound impact on during his journey from star player to first-year defensive coordinator.

What is the best possible team money could buy in 2021? NFL Media researcher Anthony Holzman-Escareno builds the ultimate 53-man roster while remaining under this year's $182.5 million salary cap.

Which roster looks best in the NFL's toughest division? Is the Rams' top-heavy blueprint built for success? Can the 49ers return to the Super Bowl with a rookie at quarterback? Gregg Rosenthal projects the starters for every team in the NFC West.

Niners running back Tevin Coleman's knee injury is expected to have him sidelined for about four weeks, coach Kyle Shanahan said. Tight end George Kittle returned to practice.

Gregg Rosenthal looks at one key homegrown player on each NFC team who could make a BIG difference in 2020. Can Leighton Vander Esch stay healthy? Will Dwayne Haskins make the leap?

Robert Saleh's sideline enthusiasm might attract the cameras, but he's actually quieter than you think he is, Steve Wyche writes. Get to know the architect of the San Francisco 49ers' elite defense.

Kirk Cousins and the Minnesota Vikings travel to Santa Clara to take on Jimmy Garoppolo and the San Francisco 49ers on Saturday. Jeremy Bergman previews the Divisional Round playoff game.

With the regular season in the rearview and the postseason on the horizon, Dan Hanzus takes a look at how all 32 teams stack up. Check out the updated Power Rankings.

With their 26-21 win over the Seattle Seahawks on Sunday night, the San Francisco 49ers clinched their first NFC West title since 2012 and home-field advantage throughout the postseason.

NFL Network's Jim Trotter reports from an instant classic on Monday night in Santa Clara, Ca., where the Seahawks prevailed over the 49ers in OT to hand San Francisco their first defeat.

The Seattle Seahawks (8-2) escaped Levi's Stadium with a nail-biting 27-24 overtime victory over the previously undefeated San Francisco 49ers (8-1) on the legs of Jason Myers.

Jelani Scott previews what to watch for as the Seattle Seahawks and San Francisco 49ers clash in an NFC West bout on "Monday Night Football."

One of San Francisco's big-ticket items on defense is done for the year. Niners starting inside linebacker Kwon Alexander is out for the remainder of the season after suffering a torn pectoral muscle.

The San Francisco 49ers held off a late charge from the Arizona Cardinals to secure a 28-25 win over their NFC West rivals and keep their perfect season alive on "Thursday Night Football."

One of John Lynch's first signings as general manager of the San Francisco 49ers is no longer in their plans. San Francisco is releasing veteran linebacker Malcolm Smith after just two seasons.

The linebacker sprung into action at a 2015 frat party to help a classmate. Her father hasn't forgotten it.

Seattle Seahawks tight end Will Dissley makes a one-handed catch but the effort is all for naught as 49ers linebacker Dre Greenlaw tackles him for a loss.

See what changes the San Francisco 49ers made to their roster this past off-season along with predictions on their best and worst case scenarios.

Former linebacker Thomas Davis lists his top four linebacker tandems in the NFL going into the 2022 NFL season.

San Francisco 49ers linebacker Dre Greenlaw ambushes Dallas Cowboys running back Ezekiel Elliott for eye-popping TFL.

Watch the San Francisco 49ers best plays from the first four weeks of the 2021 season.

NFL Network Insider Ian Rapoport details the expected timeline for San Francisco 49ers linebacker Dre Greenlaw's return from a core injury.

Watch the top plays of the week during Week 1 of the NFL 2021 season.

San Francisco 49ers linebacker Dre Greenlaw picks off Detroit Lions quarterback Jared Goff and returns the ball 39-yards for a touchdown.

Watch the highlights from the Week 7 game between the San Francisco 49ers and the New England Patriots.

Watch the best defensive plays from the San Francisco 49ers in their Week 7 matchup against the New England Patriots.

Tip drill! San Francisco 49ers safety Jaquiski Tartt picks off Arizona Cardinals quarterback Kyler Murray's batted ball for a key interception.

San Francisco 49ers STONEWALL Jacob Hollister on final play to seal win.

Watch the best defensive plays from the San Francisco 49ers in the 2019 regular season.

Watch the Seattle Seahawks vs. San Francisco 49ers highlights in Week 10 fo the 2019.

San Francisco 49ers linebacker Dre Greenlaw ends Seahawks' drive with STELLAR red-zone interception.

Watch the San Francisco 49ers vs. Arizona Cardinals highlights from Week 9 of the 2019 season.