Everything you need to know as kickoff approaches ...
Key game-time decisions
All players questionable unless noted
Harrison: Week 3 predictions
The running back returned Friday and split carries with Knile Davis. How his high ankle sprain responds prior to kickoff will determine his status and how much work he receives. UPDATE: NFL Media Insider Ian Rapoport reported Sunday that Charles' injury is more of a bruise than a high ankle sprain, and the back is a game-time decision.
Davis has missed practice all week. UPDATE: *Rapoport reports it's doubtful Davis will play after being on crutches until Thursday.*
Both were limited all week after missing last week's game. UPDATE: Both Cameron and Mingo are active.
Allen was limited Thursday and Friday. Back-to-back participation is a positive sign for his availability in Buffalo. On Sunday he was declared active.
As with last week, both are listed as questionable. Both could play again. Fantasy football fans are frustrated by this process.
Decker returned to practice on a limited basis Saturday.
Chargers at Bills -- 70 degrees / Chance of thunderstorms (83 percent)
Ravens at Browns -- 68 degrees / Chance of thunderstorms (70 percent)
Packers at Lions -- 67 degrees / Chance of thunderstorms (84 percent)
Raiders at Patriots -- 76 degrees / Chance of thunderstorms (42 percent)
Texans at Giants -- 81 degrees / Chance of rain (52 percent)
Chiefs at Dolphins -- 83 degrees / Chance of thunderstorms (59 percent)
*Forecasts courtesy of Weather Underground
Brooks: Key matchups to watch
Entering Week 3, Bucky Brooks identifies the most intriguing -- and most lopsided -- battles in games across the NFL. READ
Three matchups to watch
Plenty of people want to talk about how Peyton Manning will try to solve the riddle of the LOB. But the Broncos' offseason focus was clearly the other side of the ball. Denver wanted to get tougher. Did they? Will DeMarcus Ware, Aqib Talib and T.J. Ward make a difference against the bulldozing Lynch and magic-wand-waving Wilson? Or will "The Annihilation II: Zero Chance" take place in Seattle on Sunday afternoon?
Jackson is active to play Sunday -- and we know the chip on DJax's shoulder is weighing him down more than the sprain. Revenge games are always fun, but this has an added dose of bad blood. Jackson has said the circumstances that led to his release from the Eagles played a role in signing with the Redskins. The Eagles' defense hasn't exactly been rock-solid through two weeks. If Jackson gets loose a couple times in the secondary, oooooooh, how fun that will be to watch and listen to.
Sunday's rookie matchup to watch. Verrett, the San Diego Chargers cornerback, has been as solid as you would want a first-round CB to be in his first two weeks -- Pro Football Focus has him rated as their fifth overall cornerback at the moment. Hopefully we get to see a lot of him on fellow rookie Sammy Watkins. The Bills rookie receiver has been EJ Manuel's best field-stretching target through two weeks. Watkins' dynamic ability has the potential to wreck havoc on the Chargers' secondary. However, if Verrett and Co. are able to slow down Watkins, they could force Manuel back into check-down mode.
Did You Know?
Comebacks have been a theme around the NFL through two weeks. Teams have overcome deficits of 10-plus points to win in seven different games thus far: Atlanta, Arizona, Chicago, Green Bay, Miami and Philadelphia (twice).
The last time there were more than seven teams with comeback victories of 10-plus points through Week 2 was 1987 (eight).
Over the past five seasons, West Coast teams (SF, SD, SEA, OAK) are a combined 15-28 (.349) in games that start at 1 p.m. in the Eastern Time Zone.
Andrew Luck lost back-to-back games for the first time in his NFL career. The last time he lost back-to-back games was in 2009, when he was a redshirt freshman at Stanford.
Derek Carr has been sacked twice through two games. His brother, David Carr, was sacked 15 times in his first two games (en route to 76 during his rookie season, the most in NFL history).
Tom Brady has completed only one pass of 20-plus air yards through two games. Brady is 1 of 15 for a completion percentage of 6.7 percent on such passes.
Last week, Matt Cassel did not complete a pass of 10-plus air yards, throwing three INTs on passes of that distance. Cassel is the only player to have attempted a pass of 15-plus air yards and not have a completion. He is 0 of 9 on such passes.
From 1970 through 2012, no NFL team lost each of its first two games of the season despite holding a lead with fewer than 10 seconds remaining in the fourth quarter in each of them. Last year, the Buccaneers broke that streak, losing their first two games in that manner. The Saints joined them this season.
Colin Kaepernick's first-quarter passer rating is 136.1, while his fourth-quarter passer rating is just 48.5.
Tannehill needs one touchdown pass to surpass Don Strock (39) for sole possession of fourth place in team history.
Seattle has lost 33 games in a row when allowing 27 or more points. Denver has scored 27 or more in 19 of their last 21 regular-season games.
The Panthers' defense has been dominant, compiling 7.0 sacks (tied for fourth-most) and six takeaways (tied for second-most) while allowing an opposing passer rating of 72.1 (fifth best) and just 10.5 points per game.