Conner (shoulder) was ruled out of Sunday's game against Los Angeles, per the team's injury report.
Sunday will mark the second straight game in which Conner has been unavailable. Without the third-year runner in Week 9, Pittsburgh rushed for 90 yards as a team, with Trey Edmunds carrying the load by gaining 73 yards on 12 carries.
Edmunds spent the week of practice resting and allowing his ribs to heal, sitting out Wednesday and Thursday before returning as a full participant Friday. He'll have to again carry the ground game, though he can expect at least some help from Jaylen Samuels, who gained just 10 yards on eight carries last week.