Mendenhall, who had 1,273 rushing yards and 13 touchdowns for the AFC champions last season, was a full participant in practice Wednesday and Thursday. When asked if Isaac Redman would make his second consecutive start, Steelers offensive coordinator Bruce Arians replied: "Rashard's the man. He's ready to go."
Arians also said Jonathan Scott would start at right tackle. Pittsburgh's former starting left tackle took over on the right side after rookie Marcus Gilbert aggravated a shoulder injury Sunday.
Gilbert, nose tackle Casey Hampton (shoulder), linebacker James Harrison (eye), guard Chris Kemoeatu (knee) and defensive end Aaron Smith (foot) all sat out a second consecutive practice Thursday.
The Associated Press contributed to this report.