Start 'Em & Sit 'Em is the ultimate weekly look at NFL matchups and how they'll affect your fantasy football team. Fantasy superstars such as Patrick Mahomes and Christian McCaffrey will not be featured in this column. All player matchups are based on a PPR scoring system. For your final starting lineup decisions, check my weekly fantasy football lineup rankings.
Start of the Week
Prescott is having the best fantasy season of his career, and he'll be a tremendous option when the Cowboys head to Detroit. Their defense has given up 19 touchdown passes and more than 20 fantasy points per game to enemy quarterbacks, so Prescott should be in for another solid stat line. He has top-five quarterback potential in this game.
Allen has been on a tremendous streak in the stat sheets, scoring 17-plus fantasy points in all but one of his last eight games, including a 25-point performance in Cleveland last week. He should continue to dominate the competition in Week 11, as he faces a Dolphins defense that surrendered 21.3 points to him back in Week 7.
The last time Garoppolo faced this week's opponent, the Cardinals, he went off for four touchdowns and 28.9 fantasy points. That's not out of the norm for Arizona, as they've allowed a top-10 quarterback in four of their last six games. If Garoppolo is without George Kittle and Emmanuel Sanders, though, downgrade him in your rankings.
Carr has scored 19-plus fantasy points in two of his last three games, and he's a nice option during the bye week when he faces the hapless Bengals. Enemy quarterbacks facing their defense have averaged a 107 passer rating and more than 23 fantasy points per game. Carr is on the waiver wire in a lot of leagues, so go get em off the wire.
Winston appears to have a bad matchup on paper against a Saints defense that's been tough on quarterbacks in recent weeks. However, they're going to be without their top cornerback, Marshon Lattimore, due to injury. Also, New Orleans has surrendered five more points per game to quarterbacks on the road as opposed to at home.
Sit of the Week
Goff has been a shell of the quarterback he was last season with just 11 touchdown passes and 14 turnovers. He's also coming off a 3.7-point stinker against the Steelers, and an upcoming matchup against the Bears makes him a big-time fade. Their defense has surrendered an average of just 14.2 fantasy points to enemy signal-callers.
The last time Murray faces the 49ers, he produced 23 fantasy points. I would suggest there was some luck involved, though, and that game was in Arizona. Now at Levi's Stadium, where the Niners have allowed two touchdown passes and the fewest fantasy points to enemy field generals, I would beware the talented rookie star this weekend.
Wentz is in the final game of what has been a stretch of brutal games against some very tough pass defenses. This week he gets the Patriots, who are coming off a bye and have allowed a combined six touchdowns to enemy quarterbacks this season. Things will get much better for Wentz, but it won't happen against New England.
Cousins is tough to sit with four teams on a bye, so I would consider this a warning ... the Broncos defense has been ridiculously tough on enemy quarterbacks. In fact, this unit has allowed an average of 227 passing yards and fewer than 10.4 fantasy points a game to the position on the road. I'd fade Cousins if possible in this matchup.
Trubisky is coming off a strong performance, but that was against the Lions at Soldier Field. Next up is a much tougher matchup on the road against a Rams defense that's allowed just 15.3 fantasy points per game to enemy quarterbacks. This could wind up being a low-scoring affair, so keep Trubisky (and Goff) on the sidelines.
Michael Fabiano is an award-winning fantasy football analyst on NFL.com and NFL Network and a member of the Fantasy Sports Writers Association (FSWA) Hall of Fame. You can follow Michael on Twitter, Facebook, YouTube and Instagram for all of the latest fantasy football news, notes and in-depth analysis!