Prater missed an extra point wide right with 4:04 left in the season opener, a miscue that nearly cost the Lions.
It just wasn't enough to avoid Indy's third straight opening day loss in a wild finish.
This time, Stafford connected with receivers who took advantage of their speed against Indy's thin secondary. He quickly got the Lions into position for Prater to atone for the earlier miss.
Stafford was 31 of 39 for 340 yards with three touchdowns and no interceptions.
Indy was called for a safety on the final play of the game, for throwing an illegal forward pass in its end zone.
Copyright 2016 by The Associated Press