Edwards was listed as the Bills' No. 3 quarterback after he missed practice all week because of a lingering groin injury sustained in the first half of Buffalo's loss to San Francisco on Nov. 30.
Also inactive for the Bills were guard Jason Whittle, offensive tackle Demetrius Bell, cornerback Dustin Fox, running back Xavier Omon and tight end Jonathan Stupar.
Jets linebacker Vernon Gholston, the No. 6 overall pick in April, was inactive for the first time this season. Gholston, a defensive end at Ohio State, has struggled as an outside linebacker in New York's 3-4 defensive scheme with no sacks. He has mainly played on special teams.
Speedy David Clowney was set to make his NFL debut in Smith's place, activated for the first time in two seasons. He led the AFC with 222 yards receiving during the preseason, but injured a shoulder and was inactive for every regular-season game.
Copyright 2008 by The Associated Press