"There was a couple times it definitely hit me in the eye and it was very noticeable," Osweiler said when asked about the laser after the game, describing the incident as "disappointing" but not why the Texans lost the game.
"It was just one small factor, but it certainly affected how I was playing and able to see downfield and whatnot."
Coach Bill O'Brien didn't have any comments on the laser, saying it was a question for NFL's security and not for him.
"Stadium security is aware of the issue," an NFL spokesman told NFL.com during the game.
The laser was seen on the field again during the second half.
ESPN's Sean McDonough said security at the stadium was trying to find the culprit and remove him or her from the stadium.