Abraham had reportedly been suffering from memory loss for more than a year before the Week 1 concussion.
It could be the end of the road for the 36-year-old. If it is, count Abraham as having a great NFL career after being picked in the first round by the New York Jets in 2000. His 133.5 sacks in a 15-year career place him ninth on the NFL's all-time list.
The loss is problematic for the Cardinals, who will sorely miss the pass rusher. Abraham earned 11.5 sacks last season and was the team's one true edge rusher.