Gholston, the Jets' first-round draft pick last year, didn't practice all week after tweaking his hamstring Monday in the team's first workouts following the bye-week break.
Despite showing some improvement since his disappointing rookie season, Gholston is still looking for his first NFL sack. Gholston said he was feeling "a lot better" Friday, but the team was being cautious so it didn't turn into a more serious injury.
Sheppard has missed five of the last six games with his injury. Ryan said Sheppard won't start but will play in a rotation with Dwight Lowery.
"Even though he's practiced fully, I don't think Lito's all the way back yet," Ryan said. "We'll evaluate to see how much he'll play. I think we'll start Dwight Lowery."
Defensive end Shaun Ellis (knee), cornerback Donald Strickland (ankle), right tackle Damien Woody (back) and wide receiver Wallace Wright (knee) all are probable.
Copyright 2009 by The Associated Press