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Colts get test with Manning out

Why to watch
The streak ends here. Peyton Manning is not going to play in this one and no one knows when he will be back. That means the Texans had best win as many games as possible before Manning does return. We might look back on this game in Week 17 and say it was when the AFC South was settled. The Colts are so reliant on Manning, plus they're built to play with the lead in terms of their pass rush and running game. They could be in for a rude awakening with an absent Manning.

Inside story
Kerry Collins has struggled in his career against Wade Phillips' defenses and Phillips is bringing his 3-4 to Houston. How will the Texans respond? Will Mario Williams slide into that DeMarcus Ware role? Are they decent enough in the secondary now? Will Brian Cushing bounce back? How Phillips handles Collins and bolsters this unit will be imperative to getting the Texans over the top.

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