The Colts have won three of the last four meetings and own a commanding 12-4 overall series lead.
Keep your eye on ...
The Jaguars' offensive line: Part of the reason for Jacksonville's demise last season was that the starting offensive line was decimated by injuries. With the unit healthy headed into this season, QB David Garrard's production should be better. He's coming off a disappointing year, largely because he was constantly under duress.
Jim Caldwell's first game as Colts head coach: With Tony Dungy in charge, Indianapolis became one of the most successful teams this decade. Dungy handpicked his successor, Caldwell, who takes over for the retired coach. He is getting thrown into the fire immediately against the division rival Jaguars.
Peyton Manning's confidence in Anthony Gonzalez: For the first time in his career, Manning enters a season without Marvin Harrison to throw to in key moments. Gonzalez is stepping in for Harrison and his chemistry has grown with Manning over the past two years. Whether that chemistry ever gets to the level Manning had with Harrison remains to be seen.
Did you know?
Jaguars CB Rashean Mathis has a franchise record 25 interceptions in his career. ... Colts DE Robert Mathis tied a career-high in sacks last year with 11.5. ... Indianapolis TE Dallas Clark has 17 TD catches over the past two seasons -- tied with Antonio Gates for the most in the NFL at that position during that time span.