Cadillac Williams rushed for 128 yards to lead the Buccaneers past the Bills, 19-3, on Sept. 18, 2005.
Tampa Bay has won six of the past seven meetings against Buffalo and has a 6-2 overall series edge.
Keep your eye on ...
Byron Leftwich finding Antonio Bryant: In his Buccaneers' debut, Leftwich was sharp, throwing for 276 yards and a touchdown against the Cowboys. His only blemish was being unable to locate the best receiver on the team -- Bryant. If Leftwich can continue his solid play and do a better job of hitting Bryant on the deep ball, the Bucs could have a dangerous offense.
The Bucs' defensive identity: Ever since former defensive coordinator Monte Kiffin departed with four games to go in 2008, Tampa Bay has been on a tail spin defensively. The Bucs showed no signs of recovering from their defensive lapses in Week 1, giving up 462 total yards to the Cowboys.
Buffalo moving on after a brutal Week 1 loss: For the third consecutive season, the Bills suffered a heartbreaking loss on Monday Night Football. Buffalo must recover quickly from the defeat to avoid starting 0-2 in a very competitive AFC East.
Did you know?
This will be Tampa Bay's first trip to Buffalo in club history. ... When Williams has 22-plus rushing attempts, the Bucs are 10-0. ... Bills DE Aaron Schobel had his first career interception return for a touchdown last week.