The 2012 first-team All-Pro will have his 78-game consecutive starts streak snapped. He was listed as questionable on the Texans' injury report with a toe injury, but did not practice Friday.
Brown's injury continues a terrible week for left tackles. The Denver Broncos lost Ryan Clady for the season, and the Seattle Seahawks placed Russell Okung on short-term IR. Brown's injury doesn't appear as severe as either of them.
Ryan Harris will replace Brown in Houston's starting lineup. Harris has started 36 NFL games in six seasons, but any replacement is a huge drop off from Brown. The Texans will have to send Harris some help to keep Terrell Suggs from harassing Matt Schaub all game.