The script is tweaked in 2012, with Manning trading in the blue and white for ghastly orange. With the Denver Broncos heading to Foxborough on Sunday, here's a list of the five greatest Tom-Peyton showdowns.
This was the game where the Patriots-Colts mystique first started to take shape. The Patriots built up a 31-10 lead early in the third quarter, but -- as we came to learn in subsequent meetings -- no lead is safe in this rivalry. Late in the fourth quarter, the Colts trailed 38-34 with the ball at the Patriots' goal line. On fourth down, Willie McGinest -- who injured his knee earlier in the drive (this is debatable) -- darted through the line to bury Edgerrin James, saving the Patriots in the process.
In a matchup of undefeated teams, the Patriots wiped out a 10-point deficit with less than 10 minutes to play to exact revenge, following a bitter loss in the AFC title game earlier that year. The Patriots moved to 9-0, then won nine more before that game.
This is the game that always will be remembered for Bill Belichick's fateful decision to go for it on fourth-and-2 from his own 33. The Patriots couldn't convert (this also is debatable), Manning took over and scored in four plays to move the Colts to 9-0. A Sunday night classic.
The nadir of Manning's career (that doesn't involve multiple neck surgeries). A four-interception meltdown that swung public opinion in the "Brady or Manning?" debate. After the loss, then-Colts president Bill Polian -- upset with the Patriots' hyper-physical secondary play -- pleaded with the NFL's Competition Committee to better enforce defensive holding and illegal contact. The league agreed with Polian, a decision that continues to have huge ramifications on the sport.
Manning saved his legacy with this one. The Colts trailed 21-3 late in the second quarter but came all the way back in route to Manning's first -- and still only -- Super Bowl title. It was the first in a string of bitter playoff defeats to come for Brady.
Follow Dan Hanzus on Twitter @danhanzus.