Kolb is dealing with a fairly significant sprained foot, as well as a turf toe injury that he suffered during a Week 8 loss at Baltimore. According to the Cardinals' official website, Kolb said Tuesday on KGME-AM that a bone bruise "has shown its face" in the last couple of days and he is "touch and go" to practice Wednesday.
The Cardinals acquired Kolb in an offseason trade with the Eagles, with whom he started seven games in four years, sending cornerback Dominique Rodgers-Cromartie and a 2012 second-round draft pick to Philadelphia.
John Skelton is in line to take first-team practice reps with the Cardinals, who are skeptical about Kolb's availability this week. Skelton was 20-of-35 passing for 222 yards and one touchdown in Sunday's overtime victory over the St. Louis Rams.
Follow Jason La Canfora on Twitter @JasonLaCanfora.