The numbers tell it all.
Exactly 227 consecutive starts.
Eleven playoff appearances.
Eleven double-digit winning seasons.
Eight division crowns.
Two AFC titles.
One Super Bowl championship.
He won't this weekend.
Manning will be in street clothes when the team opens the season at Houston, still recovering from neck surgery while Kerry Collins starts in his place.
"It's going to be a little different without Peyton," Colts coach Jim Caldwell said. "He's one of a kind. When you look across our league, most teams have had quarterbacks that have missed time. Ours has just been highly unusual."
Colts vice chairman Bill Polian made it clear in a Wednesday interview with ESPN Radio New York that Indianapolis no longer is working off a timetable for Manning's return.
When asked if the quarterback could be lost for the season, Polian made no promises one way or the other.
"I honestly don't know," he said. "The doctors tell you that these things have a way of speedily recovering when the nerve regenerates, but you have no way of knowing when it will. ... They have all seen signs of improved function, which would indicate that it's going to come back, and no one doubts that, but there's no way to put a date on it."
Manning's streak is the second longest in history among NFL quarterbacks, behind only Brett Favre, whose 297-game run -- 321 including the postseason -- ended last season just before he called it a career.
Colts left tackle Anthony Castonzo was 10 years old when Manning's streak began. Veteran center Jeff Saturday has never snapped the ball to another quarterback to start a game during his pro career. In fact, no player on Indy's roster has participated in a regular-season or playoff game for the Colts without No. 18 at the controls.
New York Giants quarterback Eli Manning, Peyton's younger brother, will hold the longest active streak for a quarterback with 110 starts, including postseason play. He said he hadn't talked to his brother for a few weeks.
"I know he was dealing with a lot," the younger Manning said. "I don't know how he is feeling and what's going on. I know he wants to be out there. He gave his all, and he will give his all to be back out there."
The Colts had hoped Peyton Manning, 35, would recover while they developed a backup plan. Collins, who was brought out of retirement just two weeks ago to run the Colts' pass-heavy offense, has been preparing as though he would start.
"I expect to run the offense, bottom line," Collins said. "Make plays when they're there, be smart with the ball, make good reads, good decisions, get us into the right plays when the situation calls for it. I'm going into this week thinking I'm going to run the offense as best I can."
"Obviously, we're not used to not having him (Manning) out there," Freeney said. "He's a great player. There are 52 other guys on the team, and one guy does not win the game."
"I think he's a hell of a player," Texans coach Gary Kubiak said of Collins. "He's been successful against us. My focus right now is on our team. We've got to get ourselves ready to play. It doesn't matter who you play, or whatever, it matters how you play in this business. We've got to prepare to get ready to win a game."
Manning had been listed as doubtful for the game, but losing him for any time is a shock to Colts fans, not to mention his teammates. Not only has the four-time NFL MVP never missed a start, he has rarely missed practice.
Manning sat out one week of training camp in 1998 before signing his rookie contract. A decade later, he missed all of training camp in 2008 because he underwent surgery twice to remove an infected bursa sac from his left knee.
The only other time Manning's playing status was in doubt was 2001 after he was injured at Minnesota during a preseason game.
"To say I am disappointed in not being able to play is an understatement," Manning said in a statement released by the Colts. "The best part about football is being out there on the field playing with my teammates. It will be tough not to be out there playing for the organization and our fans. I simply am not healthy enough to play, and I am doing everything I can to get my health back. The team will do fine without me, and I know for sure that I will miss them much more than they miss me."
Manning had neck surgery to repair a nerve May 23, but the recovery has taken much longer than the expected 6 to 8 weeks that would have put him back on the field for the start of training camp. Instead, he started camp on the physically unable to perform list and wasn't activated until last Monday.
Manning did limited work at practice last week, which led to complaints about back pain. The Colts issued a statement saying that team doctors had re-evaluated Manning and instructed him to stop practicing while he undergoes more tests. No additional surgery has been scheduled.
Caldwell said the bad news only became clear Wednesday.
"We always knew it was a chance," he said. "That's what doubtful means. You always have to prepare for the worst and hope for the best."
Caldwell said he had confidence in Collins.
"The guy's thrown for 40,000 yards," Caldwell said. "He can throw the ball."
Collins has made 177 career starts and been to two Pro Bowls. He took the Carolina Panthers to the 1996 NFC Championship Game and the New York Giants to the Super Bowl after the 2000 season. He helped the Titans post the AFC's best record (13-3) in 2008.
Still, Collins has had less than two weeks to learn the Colts' offense, which has traditionally called plays at the line of scrimmage. He didn't play with perrenial Pro Bowl selections Reggie Wayne or Dallas Clark in a preseason game, and the Colts will open the season with three new starters on the offensive line and a fourth, former right tackle Ryan Diem, moving inside to guard.
Collins also carries the expectations of fans hoping Indy can become the first host team to play in the Super Bowl in February.
Collins said he's ready to step in and lead the Colts.
"I really do feel like I've come a long way in a short period of time," he said. "Now that we're into game planning, things are a little more focused and a little more centralized on what we're trying to accomplish. My comfort level is still pretty high."
The Associated Press contributed to this report.