Top runs | Week 16

Watch the top runs from Week 16 of the 2025 NFL season.

San Francisco 49ers head coach Kyle Shanahan talks to the media after Week 16 win against the Indianapolis Colts about goals for the remainder of the 2025 NFL season.

Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Watch the best plays from San Francisco 49ers running back Christian McCaffrey's 146-yard game against the Indianapolis Colts in Week 16 of the 2025 NFL season.

Watch the best plays from San Francisco 49ers tight end George Kittle's 115-yard game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.

Watch the best plays from Indianapolis Colts quarterback Philip Rivers' 277-yard, two-touchdown game against the San Francisco 49ers in Week 16 of the 2025 NFL season.

Watch the top catches from Week 16 of the 2025 NFL season.

Watch the top plays from Week 16 of the 2025 NFL season.

Watch the top defensive plays from Week 16 of the 2025 NFL season.

Watch the top touchdowns from Week 16 of the 2025 NFL season.

Watch the best plays from San Francisco 49ers quarterback Brock Purdy's 5-touchdown game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.

Indianapolis Colts quarterback Philip Rivers throws a deep 33-yard pass to wide receiver Alec Pierce.

San Francisco 49ers linebacker Dee Winters ices Indianapolis Colts with huge 74-yard pick-six against quarterback Philip Rivers.

Indianapolis Colts cornerback Camryn Bynum takes advantage of the missed catch by San Francisco 49ers wide receiver Kendrick Bourne to secure an interception.

San Francisco 49ers defensive tackle Alfred Collins sacks Indianapolis Colts quarterback Philip Rivers, who fumbles the ball that is recovered by the Colts 5-yard line.

San Francisco 49ers QB Brock Purdy notches his fifth TD of the night as he finds RB Christian McCaffrey for the score.

San Francisco 49ers running back Christian McCaffery bolts out of the backfield for a 24-yard gain.

San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings.

Indianapolis Colts running back Jonathan Taylor sneaks into the end zone for a 1-yard touchdown.

Indianapolis Colts quarterback Philip Rivers completes a 19-yard pass to tight end Tyler Warren.

San Francisco 49ers kicker Eddy Piñeiro makes a 38-yard field goal.

San Francisco 49ers wide receiver Jauan Jennings leaps to secure 19-yard pass from quarterback Brock Purdy.

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal.

San Francisco 49ers quarterback Brock Purdy completes a 3-yard touchdown pass to wide receiver Jauan Jennings.

San Francisco 49ers quarterback Brock Purdy rolls out of the pocket to locate tight end George Kittle for a 15-yard gain.