Can't-Miss Play: Another one! Harris scores pick-six

San Francisco 49ers quarterback Brock Purdy launches back-shoulder touchdown dart to 49ers wide receiver Deebo Samuel despite intense pressure.

San Francisco 49ers wide receiver Deebo Samuel breaks FOUR tackles on a 40-yard run after the catch.

Pittsburgh Steelers linebackers Alex Highsmith and T.J. Watt combine for Steelers second defensive touchdown vs. the Cleveland Browns on a strip sack of quarterback Deshaun Watson.

Cleveland Browns running back switches fields and hits the gas peal on a 69-yard rush the nearly ends in the touchdown.

Pittsburgh Steelers quarterback Kenny Pickett stands in the pocket and delivers a slant to wide receiver George Pickens who sprints 71 yards for a go-ahead touchdown on 'Monday Night Football'.

New Orleans Saints wide receiver Chris Olave's UNREAL 42-yard catch requires multiple viewings.

On the first play of the game, Pittsburgh Steelers linebacker Alex Highsmith picks off a deflected pass from Cleveland Browns quarterback Deshaun Watson and returns it 30 yards for the opening touchdown on 'Monday Night Football'.

New England Patriots safety Brenden Schooler's perfectly timed running start sets up a HUGE blocked field goal.

Denver Broncos quarterback Russell Wilson's 50-yard Hail Mary heave is caught at the buzzer by wide receiver Brandon Johnson, bringing the Broncos within a two-point conversion of sending the game against the Washington Commanders into overtime.

San Francisco 49ers cornerback Deommodore Lenoir snags a clutch interception off Los Angeles Rams quarterback Matthew Stafford late in the fourth quarter.

New York Giants quarterback Daniel Jones flashes cannon on 31-yard bomb to wide receiver Jalin Hyatt in fourth quarter as Hyatt elevates to come up with the crucial catch.

San Francisco 49ers receiver Deebo Samuel puts multiple Los Angeles Rams defenders on skates en route to the end zone for a touchdown.

New York Giants running back Saquon Barkley's pylon-reach TD pulls Giants within one score as he stretches fully out to reach the end zone on a 9-yard toss from quarterback Daniel Jones.

San Francisco 49ers wide receiver Jauan Jennings bodies up Los Angeles Rams cornerback Cobie Durant for a juggling 31-yard grab.

Washington Commanders quarterback Sam Howell dials up a deep ball to wide receiver Terry McLaurin for a 30-yard touchdown catch amid multiple Denver Broncos defenders.

Washington Commanders quarterback Sam Howell unloads a majestic 35-yard pass to tight end John Bates.

New York Giants quarterback Daniel Jones' 14-yard TD run gives Giants first points of 2023 as Jones keeps it and rushes outside for the score.

New York Giants quarterback Daniel Jones unleashes 58-yard bomb to wide receiver Jalin Hyatt as the rookie hauls in his first NFL catch.

New York Jets quarterback Zach Wilson lasers a pass to wide receiver Garrett Wilson for a 68-yard touchdown connection in Week 2 of the 2023 season vs. the Dallas Cowboys.

Denver Broncos quarterback Russell Wilson dials up a deep ball to wide receiver Marvin Mims Jr. for a 54-yard gain.

Denver Broncos quarterback Russell Wilson uncorks a 60-yard touchdown pass to wide receiver Marvin Mims Jr.

Arizona Cardinals quarterback Joshua Dobbs enters Beast Mode on 23-yard TD run as he accelerates through the defense on his was to paydirt.

Seattle Seahawks wide receiver Tyler Lockett scores game-winning TD in OT via pylon reach on a 6-yard toss from quarterback Geno Smith to give the Seahawks the win.

Tennessee Titans kicker Nick Folk delivers game-winning 41-yard FG in overtime to knock off the Los Angeles Chargers 27-24 as the Titans secure their first victory of 2023.

Kansas City Chiefs quarterback Patrick Mahomes' sudden-stop move sparks 54-yard dime to wide receiver Skyy Moore.