Flowers' lack of height caused him to be underestimated as a quarterback heading into high school and college. NFL general managers have to decide whether he has the consistent accuracy from the pocket to lead an NFL offense, but his speed and agility with the ball in his hands and his ability as a playmaker are unquestioned. The four-star recruit and All-Dade County pick as a high school senior (6,042 passing yards, 2,002 rushing yards in his career) signed on to USF because they believed in his ability as a passer. He played in five games as a true freshman, starting once (8-20, 111 yards, two interceptions; 13-73 rushing). Flowers then took over the starting role as a sophomore, leading the USF offense to a school record 5,741 yards of total offense and earning the team's MVP award. He completed 163 of 276 throws (59.1 percent) for 2,296 yards, 22 touchdowns, and eight interceptions while rushing for 991 yards and 12 scores on 191 carries. Flowers excelled as a junior, garnering the American Athletic Conference's Offensive Player of the Year award as a first-team All-Conference pick. He set a school record for rushing yards (1,530) and scores (18) while ranking fourth in the country with 7.7 yards per carry. Flowers also completed 62.5 percent of his passes for 2,807 yards and 24 touchdowns against eight picks. He was the Birmingham Bowl MVP, as well, leading the Bulls to a win over South Carolina (105 rushing yards, three rushing scores, 261 passing yards, two passing touchdowns). While he was relegated to second-team All-Conference in 2017, Flowers still led the school to a 10-2 record and a Birmingham Bowl win over Texas Tech. He started all 12 games (53.1 completion percentage, 2,911 yards, 25 touchdowns passing, six interceptions; 1,078 yards, 11 scores rushing). Flowers lost both of his parents as a youth (father to an accidental shooting, mother to cancer), but is now a father to a young daughter. His stepbrother was also shot and killed just days before he started his first game with the Bulls in 2014.