Details: Thursday, 7 p.m. ET, ESPN
What's at stake? The ACC's Coastal Division takes a significant turn with this game, as both teams are unbeaten in conference play. New Panthers coach Pat Narduzzi has his team at 6-1 despite the loss of star rusher James Conner to an early-season injury.
Matchup to watch: North Carolina CB M.J. Stewart vs. Pittsburgh WR Tyler Boyd.

Game picks:
Brandt: Pittsburgh, 27-24
Brooks: North Carolina, 22-20
Davis: North Carolina, 34-31
Goodbread: Pittsburgh, 21-14
Jeremiah: Pittsburgh, 24-21
Reuter: Pittsburgh, 26-23
Zierlein: North Carolina, 24-23

Details: Saturday, 3:30 p.m. ET, ESPN
What's at stake? The Cowboys need the road win here against Kliff Kingsbury's high-flying offense in order to keep pace with Baylor and TCU in the Big 12.
Matchup to watch: Oklahoma State DE Emmanuel Ogbah vs. Texas Tech OL Le'Raven Clark.

Game picks:
Brandt: Oklahoma State, 47-40
Brooks: Oklahoma State, 31-28
Davis: Oklahoma State, 52-48
Goodbread: Texas Tech, 35-28
Jeremiah: Oklahoma State, 38-28
Reuter: Texas Tech, 48-45
Zierlein: Texas Tech, 41-34

Details: Saturday, 7 p.m. ET, ESPN
What's at stake? Michigan, with a week off since its shocking loss to Michigan State, looks to regroup here. Minnesota's had a tough year so far (4-3, 1-2), and Gophers head coach Jerry Kill resigned this week for health reasons. A home win over Michigan would provide the kind of skin on the wall that the program can turn its season on.
Matchup to watch: Michigan WR Amara Darboh vs. Minnesota CB Eric Murray.

Game picks:
Brandt: Minnesota, 20-17
Brooks: Michigan, 17-0
Davis: Michigan, 27-10
Goodbread: Minnesota, 20-17
Jeremiah: Minnesota, 17-14
Reuter: Michigan, 24-21
Zierlein: Michigan, 23-20

Details: Saturday, Noon ET, ESPN
What's at stake? The Rebels still control their fate in the SEC West, but a road loss here would cost them that control. Auburn's season has come unglued and a four-overtime loss to Arkansas last week didn't help. An Auburn win here would help rival Alabama in the standings.
Matchup to watch: Ole Miss WR Laquon Treadwell vs. Auburn CB Jonathan Jones.

Game picks:
Brandt: Ole Miss, 28-20
Brooks: Ole Miss, 28-24
Davis: Ole Miss, 45-35
Goodbread: Ole Miss, 31-20
Jeremiah: Ole Miss, 31-24
Reuter: Ole Miss, 31-21
Zierlein: Ole Miss, 28-16

Details: Saturday, 3:30 p.m. ET, ABC/ESPN2
What's at stake? With Georgia Tech's upset over FSU last week, Clemson now stands as the last unbeaten team in the ACC. Can the Tigers hold onto the view from the top without getting dizzy?
Matchup to watch: Clemson WR Artavis Scott vs. North Carolina State CB Juston Burris.

Game picks:
Brandt: Clemson, 33-21
Brooks: Clemson, 40-30
Davis: Clemson, 42-30
Goodbread: Clemson, 42-17
Jeremiah: Clemson, 48-17
Reuter: Clemson, 35-24
Zierlein: Clemson, 27-17

Details: Saturday, 10:30 p.m. ET, ESPN
What's at stake? The two teams atop the Pac-12 North meet here with the division lead at stake. The game couldn't be more of a contrast in offenses, with Stanford's old-school rushing attack against WSU's scheme, which puts the ball in the air down after down.
Matchup to watch: Stanford CB Ronnie Harris vs. Washington State WR Dom Williams.

Game picks:
Brandt: Stanford, 41-27
Brooks: Stanford, 30-20
Davis: Stanford, 35-25
Goodbread: Stanford, 30-24
Jeremiah: Stanford, 38-28
Reuter: Stanford, 31-21
Zierlein: Stanford, 35-24

Details: Saturday, 3 p.m. ET, FOX
What's at stake? As bad as the season has been for USC, the Trojans still aren't out of the Pac-12 South race. Jared Goff and the Golden Bears have been held to 24 points in each of their last two games (back-to-back Pac-12 losses). In that league, 24 points won't sustain a championship run.
Matchup to watch: USC CB Adoree' Jackson vs. Cal QB Jared Goff.

Game picks:
Brandt: USC, 41-31
Brooks: USC, 28-24
Davis: USC, 48-40
Goodbread: USC, 38-34
Jeremiah: USC, 42-28
Reuter: USC, 34-27
Zierlein: USC, 28-24

Details: Thursday, 7:30 p.m. ET, FOXS1
What's at stake? The Horned Frogs nipped WVU by just a point last year, so despite the Mountaineers' miserable three-game Big 12 skid, TCU shouldn't be caught sleeping. A TCU defense that's been injury-depleted this year could give out at some point.
Matchup to watch: West Virginia DB KJ Dillon vs. TCU WR Josh Doctson.

Game picks:
Brandt: TCU, 49-35
Brooks: TCU, 38-35
Davis: TCU, 55-45
Goodbread: TCU, 48-28
Jeremiah: West Virginia, 34-33
Reuter: TCU, 52-21
Zierlein: TCU, 35-31

Details: Saturday, 8 p.m. ET, ABC
What's at stake? The Group of Five conferences couldn't ask for a bigger stage on which to slay a heavy Power Five favorite than the opportunity the 7-0 Owls have against the Fighting Irish.
Matchup to watch: Notre Dame OG Nick Martin vs. Temple LB Tyler Matakevich.

Game picks:
Brandt: Notre Dame, 34-17
Brooks: Notre Dame, 21-20
Davis: Notre Dame, 32-30
Goodbread: Notre Dame, 35-13
Jeremiah: Notre Dame, 21-17
Reuter: Notre Dame, 35-17
Zierlein: Notre Dame, 30-14

Details: Saturday, 3:30 p.m. ET, CBS
What's at stake? The SEC East, basically. The winner will be on top of the division with just two conference games left to play, and with hopes intact for an SEC title. Florida shocked Georgia last year in an upset and opened the door for Missouri to win the East again.
Matchup to watch: Florida LB Antonio Morrison vs. Georgia RB Sony Michel.

Game picks:
Brandt: Georgia, 20-17
Brooks: Florida, 13-10
Davis: Florida, 27-21
Goodbread: Georgia, 21-17
Jeremiah: Florida, 24-21
Reuter: Florida, 35-28
Zierlein: Florida, 23-21