Details: Saturday, 3:30 p.m. ET, CBS
What's at stake? Butch Jones wasn't supposed to be explaining the up-and-coming Volunteers' fourth loss of the year by mid-October, but that's exactly what he'll be doing if he drops this one. Georgia fans will be looking for an immediate rebound from the Bulldogs' disastrous performance at home against Alabama last week.
Matchup to watch: Georgia WR Malcolm Mitchell vs. Tennessee CB Cam Sutton

Game picks:
Brandt: Georgia, 31-28
Brooks: Georgia, 21-20
Davis: Tennessee, 28-27
Goodbread: Tennessee, 26-24
Jeremiah: Georgia, 34-24
Reuter: Georgia, 28-21
Zierlein: Georgia, 27-21

Details: Saturday, 7 p.m. ET, ESPN
What's at stake? The Razorbacks are aiming for back-to-back wins over Tennessee and Alabama, a feat that would go a long way toward washing out the taste of a three-game losing streak in September. Crimson Tide QB Jake Coker played his best game Saturday against Georgia, but must build on that success against Arkansas.
Matchup to watch: Arkansas RB Alex Collins vs. Alabama DL Jarran Reed

Game picks:
Brandt: Alabama, 27-17
Brooks: Alabama, 23-20
Davis: Alabama, 41-24
Goodbread: Alabama, 28-17
Jeremiah: Alabama, 28-21
Reuter: Alabama, 24-17
Zierlein: Alabama, 28-14

Details: Saturday, 3:30 p.m. ET, ABC/ESPN2
What's at stake? Can Clemson avoid a letdown after a big emotional win over Notre Dame? It will face a wounded Georgia Tech team that's been disappointing this year, but one that can equalize with its triple-option offense in any given week. Put this game on upset alert.
Matchup to watch: Georgia Tech QB Justin Thomas vs. Clemson DE Shaq Lawson

Game picks:
Brandt: Clemson, 31-21
Brooks: Georgia Tech, 24-20
Davis: Clemson, 30-28
Goodbread: Clemson, 35-24
Jeremiah: Clemson, 24-23
Reuter: Clemson, 38-21
Zierlein: Clemson, 28-24

Details: Saturday, 7 p.m. ET, ESPN2
What's at stake? Oklahoma State can close out the first half of the season with a surprising 6-0 mark, and 3-0 in Big 12 play, with a win over the Mountaineers. For WVU, it's a must-win game to get back into the conference race.
Matchup to watch: Oklahoma State WR David Glidden vs. West Virginia DB KJ Dillon

Game picks:
Brandt: Oklahoma State, 28-27
Brooks: Oklahoma State, 33-20
Davis: West Virginia, 42-35
Goodbread: West Virginia, 31-24
Jeremiah: West Virginia, 31-28
Reuter: West Virginia, 31-28
Zierlein: West Virginia, 35-34

Details: Saturday, Noon ET, ABC
What's at stake? The annual Red River Showdown could be a river of embarrassment for the Longhorns if they don't play better against the rival Sooners than they did last week against TCU. Don't expect OU to show any mercy if the score gets out of control.
Matchup to watch: Oklahoma LB Eric Striker vs. Texas QB Jerrod Heard

Game picks:
Brandt: Oklahoma, 38-20
Brooks: Oklahoma, 55-3
Davis: Oklahoma, 44-20
Goodbread: Oklahoma, 41-7
Jeremiah: Oklahoma, 48-28
Reuter: Oklahoma, 35-17
Zierlein: Oklahoma, 31-21

Details: Saturday, 7:30 p.m. ET, SECN
What's at stake? Yes, somehow, that's Florida at the top of the SEC East with a 3-0 conference record. And Missouri, the division's two-time defending champion, could be all but out of the race with a second SEC loss here. QB Maty Mauk is suspended once again, so the Gators have an ideal chance to snatch a key road win here.
Matchup to watch: Florida WR Demarcus Robinson vs. Missouri CB Aarion Penton

Game picks:
Brandt: Florida, 17-13
Brooks: Florida, 23-20
Davis: Florida, 31-30
Goodbread: Florida, 30-20
Jeremiah: Florida, 24-17
Reuter: Florida, 28-10
Zierlein: Florida, 30-27

Details: Saturday, 8 p.m. ET, ABC
What's at stake? The rivalry of the 1990s in college football renews in Tallahassee with a little less hype than the series used to enjoy. With Hurricanes fans still wondering if Al Golden is the right man to lead the program, a road upset over the defending ACC champions would go a long way toward quieting Golden's critics.
Matchup to watch: Miami QB Brad Kaaya vs. Florida State DB Jalen Ramsey

Game picks:
Brandt: Florida State, 24-21
Brooks: Florida State, 24-20
Davis: Florida State, 38-21
Goodbread: Florida State, 28-21
Jeremiah: Florida State, 31-21
Reuter: Florida State, 31-21
Zierlein: Florida State, 24-21

Details: Saturday, 7:30 p.m. ET, FOX
What's at stake? With Oklahoma, Baylor, TCU and Oklahoma State all still unbeaten in Big 12 play, Kansas State can all but forget about any conference title aspirations if it loses at home to the Horned Frogs.
Matchup to watch: TCU WR Josh Doctson vs. Kansas State DB Morgan Burns

Game picks:
Brandt: TCU, 37-27
Brooks: TCU, 40-28
Davis: TCU, 40-27
Goodbread: TCU, 45-28
Jeremiah: TCU, 35-27
Reuter: TCU, 45-31
Zierlein: TCU, 49-31

Details: Saturday, 3:30 p.m. ET, BTN
What's at stake? This is a dangerous game for the 4-1 Wolverines. Northwestern (5-0) is playing some of the best defense in the nation, having already recorded two shutouts, and Michigan's offense isn't exactly explosive. Of course, Michigan's defense has shut out its last two opponents. With Michigan State looming next week, the Wolverines can ill-afford to look ahead to a rivalry game.
Matchup to watch: Northwestern DE Dean Lowry vs. Michigan RB De'Veon Smith

Game picks:
Brandt: Michigan, 16-13
Brooks: Michigan, 17-14
Davis: Michigan, 27-24
Goodbread: Michigan, 21-13
Jeremiah: Michigan, 17-14
Reuter: Michigan, 21-17
Zierlein: Michigan, 27-17

Details: Saturday, 10 p.m. ET, ESPN
What's at stake? It's a matchup of two of the three teams in the Pac-12 that still haven't incurred a conference loss. Cal QB Jared Goff will face the toughest defense he's seen this season. A Utah loss would throw the Pac-12 South standings into a wild race.
Matchup to watch: Cal QB Jared Goff vs. Utah DB Marcus Williams

Game picks:
Brandt: Utah, 37-30
Brooks: Utah, 24-20
Davis: Utah, 48-45
Goodbread: Utah, 31-28
Jeremiah: California, 27-26
Reuter: Utah, 35-31
Zierlein: Utah, 34-28