Details: Saturday, Noon ET, ESPN
What's at stake? Entering with a combined 7-1 record, it's the Big Ten opener for both schools and, for new Wisconsin coach Paul Chryst, a chance to endear himself to Badgers fans in his first conference home game. Iowa would like to recapture the Heartland Trophy for the first time since 2009.
Matchup to watch: Iowa QB C.J. Beathard vs. Wisconsin LB Joe Schobert

Game picks:
Brandt: Wisconsin, 21-17
Brooks: Wisconsin, 27-26
Davis: Wisconsin, 27-20
Goodbread: Wisconsin, 20-13
Jeremiah: Wisconsin, 28-21
Reuter: Wisconsin, 24-17
Zierlein: Iowa, 24-20

Details: Saturday, Noon ET, ABC
What's at stake? For TCU, it's just another step toward what could be a Big 12 title. For Texas, it's more. Charlie Strong needs to notch a signature win this season, and with TCU's defense decimated by injury, this could be the day.
Matchup to watch: Texas CB Duke Thomas vs. TCU WR Josh Doctson

Game picks:
Brandt: TCU, 41-28
Brooks: TCU, 45-40
Davis: TCU, 55-21
Goodbread: TCU, 45-21
Jeremiah: TCU, 38-28
Reuter: TCU, 49-34
Zierlein: TCU, 49-21

Details: Saturday, 7:30 p.m. ET, FOX
What's at stake? ASU has been blown out of both its games against Power Five opponents, so the Sun Devils have something to prove here.
Matchup to watch: Arizona State LB Salamo Fiso vs. UCLA RB Paul Perkins

Game picks:
Brandt: UCLA, 37-20
Brooks: UCLA, 17-14
Davis: UCLA, 45-41
Goodbread: Arizona State, 28-24
Jeremiah: Arizona State, 28-24
Reuter: UCLA, 35-21
Zierlein: UCLA, 40-20

Details: Saturday, 3:30 p.m. ET, ABC/ESPN2
What's at stake? The reputation of both defenses, for one thing. It won't be surprising if 80 or 90 points hit the scoreboard in this one.
Matchup to watch: Texas Tech WR Jakeem Grant vs. Baylor CB Xavien Howard

Game picks:
Brandt: Baylor, 51-34
Brooks: Baylor, 50-48
Davis: Baylor, 60-56
Goodbread: Baylor, 45-28
Jeremiah: Baylor, 48-35
Reuter: Baylor, 52-31
Zierlein: Baylor, 52-38

Details: Saturday, Noon ET, FOX Sports 1
What's at stake? Two ranked opponents clash here with an 0-1 start in Big 12 play awaiting the loser. Both teams enter at 6-0 between them.
Matchup to watch: West Virginia WR Shelton Gibson vs. Oklahoma CB Zack Sanchez

Game picks:
Brandt: Oklahoma, 31-24
Brooks: Oklahoma, 31-28
Davis: Oklahoma, 42-31
Goodbread: Oklahoma, 31-27
Jeremiah: Oklahoma, 45-35
Reuter: Oklahoma, 42-35
Zierlein: Oklahoma, 34-28

Details: Saturday, 7:30 p.m. ET, SEC Network
What's at stake? Is Dak Prescott's preseason standing as the SEC's top quarterback holding up? Texas A&M's Kyle Allen, with an 11-2 TD-INT ratio, is making as strong an argument against that as anyone. Unless Prescott spoils the day for the College Station home crowd, Allen might be able to make the claim after this one.
Matchup to watch: Mississippi State CB Will Redmond vs. Texas A&M WR Josh Reynolds

Game picks:
Brandt: Texas A&M, 31-27
Brooks: Texas A&M, 40-35
Davis: Texas A&M, 38-28
Goodbread: Texas A&M, 35-21
Jeremiah: Texas A&M, 35-28
Reuter: Texas A&M, 38-28
Zierlein: Texas A&M, 30-28

Details: Saturday, 7 p.m. ET, ESPN
What's at stake? Ole Miss' offense, replete with a bevy of gifted receivers, faces one of the nation's most talented defensive backfields here. The UF pass rush's ability to get to Rebels QB Chad Kelly will be crucial.
Matchup to watch: Ole Miss WR Laquon Treadwell vs. Florida CB Vernon Hargreaves

Game picks:
Brandt: Ole Miss, 27-20
Brooks: Ole Miss, 28-27
Davis: Ole Miss, 40-30
Goodbread: Ole Miss, 40-21
Jeremiah: Ole Miss, 28-27
Reuter: Ole Miss, 28-21
Zierlein: Ole Miss, 28-21

Details: Saturday, 10:30 p.m. ET, Pac-12 Network
What's at stake? The Wildcats' defense once again will have to take the field without injured LB Scooby Wright. With a win, Stanford can improve to 3-0 in Pac-12 play.
Matchup to watch: Arizona LB Jake Matthews vs. Stanford RB Christian McCaffrey

Game picks:
Brandt: Stanford, 41-27
Brooks: Stanford, 13-10
Davis: Stanford, 35-24
Goodbread: Arizona, 30-17
Jeremiah: Stanford, 31-24
Reuter: Stanford, 34-17
Zierlein: Arizona, 24-23

Details: Saturday, 3:30 p.m. ET, CBS
What's at stake? If this is Georgia's year, this is the day for the Bulldogs to prove it. UGA hasn't faced much of a schedule yet, with the league's two worst teams offering little resistance. Alabama rebounded from a loss to Ole Miss last year to reach the College Football Playoff. A loss here would dash that hope and likely dash any SEC title hopes, as well.
Matchup to watch: Alabama LB Reggie Ragland vs. Georgia RB Nick Chubb

Game picks:
Brandt: Alabama, 27-24
Brooks: Alabama, 21-20
Davis: Alabama, 24-23
Goodbread: Georgia, 21-16
Jeremiah: Alabama, 17-16
Reuter: Georgia, 27-17
Zierlein: Georgia, 24-21

Details: Saturday, 8 p.m. ET, ABC
What's at stake? Clemson needs a win here to establish a high-quality victory on its resume. Notre Dame's defense is looking championship caliber, and will get its stiffest test yet from Clemson QB Deshaun Watson.
Matchup to watch: Notre Dame OL Ronnie Stanley vs. Clemson DE Shaq Lawson

Game picks:
Brandt: Notre Dame, 30-27
Brooks: Clemson, 24-21
Davis: Clemson, 28-27
Goodbread: Clemson, 27-20
Jeremiah: Clemson, 28-21
Reuter: Notre Dame, 28-24
Zierlein: Clemson, 21-17