Details: Saturday, 3:30 p.m. ET, CBS
What's at stake? Ole Miss continues to control its path to the SEC title game -- it just can't afford another league loss. Arkansas, meanwhile, needs to finish the season strong just to be bowl-eligible.
Matchup to watch: Arkansas TE Hunter Henry vs. Ole Miss DB Tony Conner.

Game picks:
Brandt: Ole Miss, 27-20
Brooks: Ole Miss, 24-21
Davis: Ole Miss, 35-28
Goodbread: Ole Miss, 31-17
Jeremiah: Ole Miss, 24-17
Reuter: Ole Miss, 24-17
Zierlein: Ole Miss, 27-17

Details: Saturday, Noon ET, ESPNU
What's at stake? A Penn State win gets the Nittany Lions to 8-2 with two games to play, a big improvement over last year's 6-6 regular-season mark. The Wildcats had an idle date last week to try to repair a defense that was dominant in the first half of the season, but has faltered some of late.
Matchup to watch: Penn State DE Carl Nassib vs. Northwestern OT Geoff Mogus.

Game picks:
Brandt: Penn State, 16-13
Brooks: Penn State, 27-24
Davis: Penn State, 28-26
Goodbread: Penn State, 20-14
Jeremiah: Penn State, 27-24
Reuter: Northwestern, 27-20
Zierlein: Penn State, 23-21

Details: Saturday, 7 p.m. ET, ESPN2
What's at stake? Memphis continues its unbeaten push to be the "New Year's Six" bowl qualifier from the Group of Five conferences. Navy's triple-option will bring a big contrast in offenses here, and it has only lost to Notre Dame. The teams have a combined record of 14-1.
Matchup to watch: Navy CB Quincy Adams vs. Memphis QB Paxton Lynch.

Game picks:
Brandt: Memphis, 41-34
Brooks: Memphis, 30-24
Davis: Navy, 33-30
Goodbread: Memphis, 34-20
Jeremiah: Memphis, 28-21
Reuter: Memphis, 45-24
Zierlein: Memphis, 33-27

Details: Saturday, 3:30 p.m. ET, ESPN2
What's at stake? Houston is undefeated under first-year coach Tom Herman and could be on its way to a "New Year's Six" bowl bid. But with other Group of Five schools still unbeaten, a loss could cost the Cougars that goal.
Matchup to watch: Cincinnati QB Gunner Kiel vs. Houston CB William Jackson III.

Game picks:
Brandt: Houston, 41-27
Brooks: Houston, 30-28
Davis: Houston, 49-42
Goodbread: Cincinnati, 38-30
Jeremiah: Houston, 28-24
Reuter: Houston, 38-35
Zierlein: Houston, 27-20

Details: Saturday, Noon ET, ESPN2
What's at stake? The Blue Devils try to rebound from the shocking loss to Miami that their conference says shouldn't have happened. They'll try to bounce back against the rival Tar Heels -- UNC has been one of college football's biggest turnaround stories this season.
Matchup to watch: Duke DB Jeremy Cash vs. North Carolina WR Mack Hollins.

Game picks:
Brandt: North Carolina, 31-27
Brooks: North Carolina, 40-34
Davis: North Carolina, 38-31
Goodbread: North Carolina, 35-24
Jeremiah: North Carolina, 24-23
Reuter: North Carolina, 35-30
Zierlein: North Carolina, 26-21

Details: Saturday, 8 p.m. ET, ABC
What's at stake? A lot for Cardale Jones, the OSU quarterback who was benched for J.T. Barrett until an OVI citation put him back in the starting role. It's fair to assume that the job is Barrett's when he returns, but Jones could help himself a lot by showing some improvement here.
Matchup to watch: Minnesota DB Briean Boddy-Calhoun vs. Ohio State WR Michael Thomas.

Game picks:
Brandt: Ohio State, 37-10
Brooks: Ohio State, 21-17
Davis: Ohio State, 45-27
Goodbread: Ohio State, 28-13
Jeremiah: Ohio State, 35-21
Reuter: Ohio State, 28-17
Zierlein: Ohio State, 31-14

Details: Saturday, Noon ET, ABC
What's at stake? The Fighting Irish can keep themselves in the hunt for a College Football Playoff berth here, but a loss would knock them out of any consideration. Pittsburgh comes off a Thursday game, so the Panthers have had a bit more time to rest and prepare.
Matchup to watch: Notre Dame CB KeiVarae Russell vs. Pittsburgh WR Tyler Boyd.

Game picks:
Brandt: Notre Dame, 31-21
Brooks: Notre Dame, 27-20
Davis: Notre Dame, 30-23
Goodbread: Notre Dame, 30-13
Jeremiah: Pittsburgh, 21-20
Reuter: Notre Dame, 27-21
Zierlein: Notre Dame, 30-20

Details: Saturday, 3:30 p.m. ET, FOX
What's at stake? The crowded scene at the top of the Big 12 will begin to thin out with this game, as both teams are unbeaten and need to stay that way before playing Baylor. An offensive fireworks display is a certainty.
Matchup to watch: TCU OL Halapoulivaati Vaitai vs. Oklahoma State DE Emmanuel Ogbah.

Game picks:
Brandt: TCU, 45-40
Brooks: TCU, 56-54
Davis: TCU, 51-50
Goodbread: TCU, 47-35
Jeremiah: Oklahoma State, 35-34
Reuter: TCU, 52-45
Zierlein: TCU, 38-31

Details: Saturday, 3:30 p.m. ET, ABC
What's at stake? The ACC's Atlantic Division is very much on the line here, and in turn, a shot at the ACC title and the College Football Playoff berth that could come with it. FSU, having already lost to Georgia Tech, would be out of the CFP race with a loss.
Matchup to watch: FSU DB Jalen Ramsey vs. Clemson WR Artavis Scott.

Game picks:
Brandt: Clemson, 27-24
Brooks: Florida State, 31-30
Davis: Clemson, 36-24
Goodbread: Clemson, 31-24
Jeremiah: Clemson, 41-30
Reuter: Clemson, 38-28
Zierlein: Clemson, 28-20

Details: Saturday, 8 p.m. ET, CBS
What's at stake? Just a legitimate shot at every goal both teams have this season. LSU is in a better position than Alabama because the Tide already has a loss, but the winner will be squarely in the playoff conversation. LSU opened at No. 2 in the first CFB Playoff rankings, while Alabama opened at No. 4.
Matchup to watch: LSU RB Leonard Fournette vs. Alabama LB Reggie Ragland.

Game picks:
Brandt: Alabama, 28-20
Brooks: LSU, 9-6
Davis: LSU, 24-21
Goodbread: Alabama, 21-16
Jeremiah: Alabama, 17-14
Reuter: Alabama, 24-21
Zierlein: LSU, 23-21