Saints QB Drew Brees has been the most prolific passer in the NFL over the past three seasons, including 5,069 yards in 2008 to become the top fantasy quarterback. (AP Photo/Carlos Osorio)

Patriots QB Tom Brady appears healthy and ready to go. He might not pass for 50 TDs again, but expect big numbers. (AP Photo/Michael Dwyer, File)

Colts QB Peyton Manning has been the model of consistency, reaching 4,000 passing yards in nine of his last 10 seasons. Expect more of the same. (AP Photo/Denis Poroy, File)

Chargers QB Philip Rivers joined the fantasy elite with 4,009 passing yards and 34 TDs. (AP Photo/Denis Poroy)

Brett who? Packers QB Aaron Rodgers became a serious fantasy stud during his first year as a starter in Green Bay. (AP Photo/Mike Roemer)

He's not a man, he's a machine. Cardinals QB Kurt Warner was a top fantasy performer, adding another Super Bowl appearance to his Hall of Fame career. (AP Photo/Winslow Townson, File)

Make your jokes about the playoffs or Jessica Simpson, but Cowboys QB Tony Romo is a serious fantasy stud. (AP Photo/Mel Evans)

Falcons QB Matt Ryan is poised for a breakout fantasy season after a promising rookie campaign. (AP Photo/Denis Poroy)

QB Jay Cutler won't have the same caliber of receivers he had in Denver but he is still a top fantasy quarterback. (Photo by Jonathan Daniel/Getty Images)

Donovan McNabb is a top fantasy quarterback for the Eagles, despite a patchwork receiving corps. (AP Photo/Ross D. Franklin)