Jones-Drew had been one of the most durable and reliable running backs in fantasy football. Of course, that was until he held out of training camp and missed 10 games last season with an injured foot. He is expected to be ready for the start of training camp, though, and motivation shouldn't be an issue as "Pocket Hercules" is entering a contract year. Still, owners in fantasy land are still a little concerned. (AP Photo/Stephen Morton)

Amendola has everything in the world going for him from a statistical perspective. With Wes Welker, Aaron Hernandez and Brandon Lloyd out of the mix and Rob Gronkowski's status for the start of the season in doubt, he's in line to be the top option in the pass attack for Tom Brady. The problem with Amendola is his proneness to major injuries. In the last two years, he's missed 20 games. Regardless, he's well worth a roll of the dice. (AP Photo/Charles Krupa)

Brady wouldn't have been on this list (or anywhere near it) at the end of last season. He finished third in fantasy points among all players and was once again a fantasy star. But with the loss of four of his top five receivers and Rob Gronkowski's status in question, fantasy owners are now worried that the mid-30s quarterback has become at least somewhat of a risk. In fact, he is falling into the fifth round in some mock drafts. This is still Tom Brady, though, so it's hard to pass on him. (AP Photos/David Drapkin)

Murray has all the talent in the world and is a clear-cut breakout candidate in fantasy leagues. The major issue is his lack of durability, as Murray has missed a combined nine games - including six last season - during his tenure at the NFL level. With a current average draft position of Round 5, Murray is being picked as a No. 2 fantasy runner in most leagues. Owners should build backfield depth or draft Joseph Randle as a handcuff, though. (AP Photo/James D Smith)

The offseason was both good and bad for Johnson. On a positive note, the team added rookie OG Chance Warmack and veteran OG Andy Levitre to what should be a much-improved line. On the flip side, Shonn Greene is now in the mix and could steal short-yardage and goal-line work. It's also troubling that CJ2K has only scored a combined 10 touchdowns over the last two years. He's going to be much less of a risk if drafted as a No. 2 fantasy back. (AP Photo/Wade Payne)

This one isn't a shock to anyone. Mathews, a major disappointment in fantasy land, is coming off a 2012 campaign that saw him suffer more fractured collarbones (2) than he scored touchdowns (1). He's also unlikely to become a three-down back after he saw just five third-down snaps last season, not to mention the addition of Danny Woodhead. If you do draft Mathews, it shouldn't be as more than a borderline No. 3 or 4 fantasy runner. (AP Photo/Kevin Terrell)

This likely has nothing to do with Kaepernick wearing a Miami Dolphins cap, and just about everything to do with the loss of Michael Crabtree during OTAs. That was a major blow, as Crabtree was far and away Kaepernick's favorite target in the pass attack. Still, his skills as a passer (and more importantly a runner) will keep him among the 10 best fantasy quarterbacks. He's just not as attractive a breakout candidate. (AP Photo/Tom Hauck)

Has anyone seen his fantasy value come into question more than Gronkowski? Not only is he coming off multiple forearm surgeries, but he also had a procedure on his back that has his status for the start of the season up in the air. In fact, Gronkowski has fallen into the fourth round in terms of ADP on NFL.com. He's going to be worth a roll of the dice at that point, but the Arizona product is no lock to play in a full 16 games in 2013. (AP Photo/Charles Krupa)

Griffin III was the breakout rookie of last season, but an injured knee cost him one game and eventually required a reconstructive procedure to repair. All reports on his recovery have been positive to this point, but owners are still concerned about the speed at which he can return to superstar form - especially due to his slender frame. He's being picked in the fifth or sixth round, on average, in current NFL.com drafts. (AP Photo/Patrick Semansky)

McFadden, who will be 26 when the season starts, was far and away the player that scared fantasy owners the most. While he's in the prime of his career, it is a virtual guarantee that he's going to get hurt at some point. The veteran has never played in more than 13 games at the pro level, and he's also missed a combined 13 games over the last two years. There might not be a bigger risk-reward running back in 2013 fantasy football formats. (Ric Tapia/NFL)