The biggest sign pointing toward Bradford potentially sitting out is that the Rams activated quarterback Tim Brandstater from the practice squad on Saturday, giving the team a third quarterback on the active roster behind A.J. Feeley.
Rams coach Steve Spagnuolo said Bradford would be a game-time decision against the 49ers after he was very limited in Friday's practice. That assessment came after Bradford, who aggravated a high left ankle sprain in last week's loss to the Seattle Seahawks, suffered a setback and sat out Thursday's practice.
Feeley took first-team reps this week and would start in the absence of Bradford. Feeley started two games earlier this season when Bradford was initially sidelined by the injury.