Alex Smith has seven picks this year.
(Paul Spinelli / Associated Press)
Why you should watch
San Francisco running back Brian Westbrook faces his former team, not that he sees the field much. The Niners cannot afford to go 0-5, even in the lowly NFC West.
Did you know?
Philadelphia's DeSean Jackson averages 46.9 yards per touchdown in his career (18 scores). ... Eagles CB Asante Samuel leads the NFL in interceptions since 2006 with 30. ... San Francisco's Frank Gore leads all running backs with 29 catches. ... 49ers rookie Taylor Mays scored the first TD off a blocked punt since 1987 for San Francisco.