Whisenhunt said Saturday night that Kolb would likely be held out of the contest against his former team as he continues to recover from a right turf toe injury.
"The only way he'll play tomorrow would be probably in a backup role," Whisenhunt said on SiriusXM Sports.
The Cardinals listed Kolb as questionable and a game-time decision after holding him out of practice throughout the week. John Skelton is in line to start for the second consecutive week following a 19-13 win over the St. Louis Rams last week. Skelton threw for 222 yards with a touchdown in the victory.