Seattle holds an 11-4 edge in the all-time series, winning the last four meetings and Pete Carroll holds a 5-1 career record against the Bears. But this is a different Bears team from the 2015 meeting, and Chicago has a first-year coach in Matt Nagy and there is plenty of optimism for a turnaround with Nagy at the helm.
While the Bears couldn't withstand an Aaron Rodgers-led comeback in Week 1, the team showed promise in the first half en route to a 17-0 lead behind second-year quarterback Mitch Trubisky and a swarming defense before losing 24-23.
Meanwhile, what both teams hope to avoid in Week 2 is falling to 0-2 and into the basement in their divisions.
Here are five areas to watch on Monday Night Football:
1. How do the Bears handle Russell Wilson?
Wilson can put pressure on a defense with his arm and legs, and how Bears defensive coordinator Vic Fangio schemes against him will go a long way in determining the outcome of the game.
But given his time as a defensive coordinate with the San Francisco 49ers from 2011 to 2014, Fangio should be very familiar on the best practices to defend Wilson. From 2012 to 2014, Wilson posted a 4-2 record against Fangio's defenses, but the elusive signal-caller passed for more than 200 yards just once in that span, while adding 136 yards rushing and no touchdowns on 32 carries.
2. Speaking of Mack
The newest Bears defensive player totaled three tackles, a sack, a forced fumble, a fumble recovery and a 27-yard pick-six in his debut last week, and the Bears eased in Mack with 42 snaps out of the team's 60 defensive plays. Now, Mack is primed to see more action after getting acclimated to game action and the Bears' defensive playbook.
The Seahawks would be wise to consider getting Ifedi some help throughout the game or risk leaving him one-on-one against another elite pass rusher with less than desired results.
3. Can the Seahawks establish the run?
Seattle signaled a commitment to a running game during the offseason with the hiring of Brian Schottenheimer as the offensive coordinator, but now it's a matter of showing it.
If the Bears are successful in containing Wilson's ability to hurt them outside of the pocket, Carson or Penny must emerge to provide a balanced attack.
4. What will the Bears offense do?
Trubisky started off hot in Week 1, completing 11 of 14 passes for 109 yards and rushing for a touchdown before halftime. Then, he fizzled in the final two quarters, completing 12 of 21 passes for 62 yards.
Howard totaled 107 yards (82 rushing, 25 rushing) in Week 1 and he should be able to exploit a Seattle run defense that surrendered 146 yards against the Broncos.
5. Heavyweight returner battle
Lockett, who had a 30-yard return in Week 1, boasts an average of 25.7 yard per kickoff return and 8.1 yards per punt return on his career.
Cohen, who enters his second season, averaged 22.1 yards per kickoff return and 10.2 yards per punt return in his rookie season of 2017. He had two punt returns for 45 yards last week, including a 42-yard effort.
In a game of inches, look for Lockett and Cohen to have a role in determining field position to help their team's chances for a win.