Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 8 fantasy matchups.
Philadelphia Eagles at Dallas Cowboys: 8:30 p.m. ET on NBC
Darren Sproles, RB -- SIT: Sproles has had two or fewer catches in four of six games so far this year, sinking his value even in PPR formats.
Eagles WRs -- SIT: Wentz is spreading the ball around well, with no receiver seeing more than seven targets since Week 2. This group is too erratic to trust in fantasy.
Dez Bryant, WR -- FLEX: Bryant (knee) is finally back. However, he only saw more than six targets in one of his three games with Prescott. The offense doesn't funnel through Bryant any more, but his touchdown-upside makes him a decent flex.
Cole Beasley, WR -- FLEX: Beasley has three touchdowns in his last two games and has yet to post fewer than 53 yards in any game this year. He's a solid flex play with added upside in PPR formats.
Minnesota Vikings at Chicago Bears: 8:30 p.m. ET on ESPN
Sam Bradford, QB -- SIT: The combination of leading a low-volume passing game behind a shaky offensive line on the road against a surprisingly effecive Chicago defense makes Bradford a sit this week.
Jerick McKinnon, RB -- SIT: McKinnon tweaked his ankle last week, loses goal-line work to Matt Asiata, and is facing a Chicago defense allowing just 3.5 yards per carry over the last four weeks (and 3.8 ypc on the year). He was spotted in a walking boot on Thursday, too, so he's a must-bench this week.
Matt Asiata, RB -- FLEX: If McKinnon misses this game or is limited (which looks more and more likely as we approach gameday, Asiata will have flex appeal thanks to his increased touch share and his touchdown-upside as the team's preferred goal-line option.
Kyle Rudolph, TE -- START: Rudolph is like a target vacuum in Minnesota and simply cannot be benched given the issues at the tight end position.
Alshon Jeffery, WR -- START: As the starter last year, Cutler pummeled Jeffery with around 11 targets per game. Jeffery's worth starting simply in the hope that old habits die hard for this duo.
Jacksonville Jaguars at Tennessee Titans: 8:25 p.m. on NFL Network (Thursday)
Allen Robinson, WR -- FLEX: No one should be offended if you want to sit Allen Robinson. His fantasy scoring has dropped every week since he snagged two touchdowns against the Ravens in Week 3. He still leads the Jaguars in red-zone targets and targets inside the 10-yard line. That touchdown upside alone makes him tough to sit, despite the recent struggles.
Allen Hurns, WR -- SIT:The usage has been there in some weeks for Hurns, but not much production has followed. His big-play upside has even been squashed this year with his move to primarily playing slot receiver.
Marcus Mariota, QB - START: We'd put Mariota in the "good not great" streamer category of the week. Mariota has eight passing touchdowns and 138 rushing yards over his last three games, but the Jaguars passing defense isn't a sieve by any means. They've allowed the fourth-fewest passing yards in the NFL and just nine touchdowns through the air.
Rishard Matthews, WR -- SIT:With Sharpe likely out, Matthews will be the one to draw Ramsey's coverage more often than not. Ramsey has stood up well to better receivers than Matthews this season.
Washington Redskins at Cincinnati Bengals: 9:30 a.m. ET on FOX
Redskins RBs -- SIT: No one is really exciting in this group with Matt Jones fumbling and Rob Kelley expected to steal some work. If Jones, who is dealing with a knee injury, misses this game Kelley will have flex appeal, though. Chris Thompson can be a fill-in option regardless for those in PPR leagues.
DeSean Jackson, WR -- FLEX: As frustrating a player as he's ever been, Jackson is once again wildly unpredictable week-to-week. He draws a matchup against a bigger cornerback (Dre Kirkpatrick) and this game should be high-scoring. But really, who knows what you'll get?
Jeremy Hill, RB -- START: Only San Francisco is a worse run defense from an efficiency perspective than Washington. Hill should be able to punch it downhill with regularity this week.
Giovani Bernard, RB -- FLEX:Some of that positivity for Hill could spill over into Bernard's outlook, but they play such different roles in the offense. As a home favorite, it's hard to imagine this being a big Gio game.
Tyler Eifert, TE -- START:With six teams on bye, it's hard to imagine that if you have Eifert, you aren't playing him. He's bound to play more than the 25 percent of the snaps his saw in his debut.
Kansas City Chiefs at Indianapolis Colts: 1:00 p.m. ET on CBS
Jeremy Maclin, WR -- SIT: Maclin hasn't found the end zone since Week 1 and has seen seven or fewer targets in four of six games this year. Until his market share becomes more consistent, he should be benched.
Frank Gore, RB -- START: Gore has posted double-digit fantasy points in five of seven games so far, with a season low of 7.8 in Week 1. He's among the safest RB2/flex plays in the league right now.
T.Y. Hilton, WR -- START: With so many players injured, the passing offense runs through Hilton and he's producing week after week, making him impossible to sit.
Arizona Cardinals at Carolina Panthers: 1:00 p.m. ET on FOX
John Brown, WR - FLEX:Brown is on track to play and is incredibly tempting as a big-play threat against this slow defense. Brown should run plenty of routes against rookie Zach Sanchez, who has struggled big time since he's entered the starting lineup.
Jonathan Stewart, RB -- FLEX:Arizona has the 10th ranked run defense in Football Outsiders' DVOA. So, this isn't a good matchup, but Stewart is still a running back playing at home with plenty of opportunity. It's hard to say no to that in this bye and injury-heavy week.
Oakland Raiders at Tampa Bay Buccaneers: 1:00 p.m. ET on CBS
Jameis Winston, QB -- START: With these two defenses and a pair of exciting young offenses, this could be the highest-scoring game of the week. If that's the case, you want to pluck the home starting quarterback. Despite flummoxing the Jaguars in Week 7, the Raiders still lead the league in passing yards allowed.
Seattle Seahawks at New Orleans Saints: 1:00 p.m. ET on FOX
Russell Wilson, QB -- START: Wilson isn't completely healthy, but he should be good enough to shake off his fantasy doldrums. If not, it's officially panic time.
Christine Michael, RB -- START: Forget what happened last week. Everyone has occasional bad games -- especially against Arizona. This week is C-Woke's "get right" game.
Jimmy Graham, TE -- START: Did we mention that Graham has been resurrected this season? If that's not enough for you, then ... REVENGE!
Drew Brees, QB -- START: Brees' bigger games this season have come at home. That's the good news. But this is the toughest defense he's faced all year. That's the bad news.
Willie Snead, WR -- FLEX: Snead is a Swiss Army knife in the New Orleans offense, which means he could find multiple ways to get the football in his hands this week.
Detroit Lions at Houston Texans: 1:00 p.m. ET on FOX
Marvin Jones, WR -- SIT: After a hot start, Jones' targets have fallen off and he's become touchdown-dependent. A score might be hard to come by this week.
Brock Osweiler, QB -- START: This is a "break glass in case of emergency" start. Osweiler has been awful all year, but if there's anything that can help, it's Detroit's secondary.
DeAndre Hopkins, WR -- START: Right now, if you have Hopkins on your roster, you need to believe he can triumph against positive matchups. This is one of those matchups.
Will Fuller, WR -- FLEX: Fuller's only posted one good game in the last month. But this feels like a chance for him to offer some decent WR3 value in most leagues.
New England Patriots at Buffalo Bills: 1:00 p.m. ET on CBS
Julian Edelman, WR -- SIT: A touchdown-dependent receiver who's not scoring touchdowns? That's not how you win. Feel free to sit him down anytime now.
Rob Gronkowski, TE -- START: Don't sit Gronk. Don't sit Gronk. Are you thinking about sitting Gronk? You shouldn't. You shouldn't sit Gronk. Don't sit Gronk.
Tyrod Taylor, QB -- SIT: How Taylor has continued to succeed despite any real weapons is a mystery. It will be hard to count on that again this week.
Robert Woods, WR -- SIT: We know there are six teams on a bye. But are you really that shorthanded at WR? Oh, you are? Well ... good luck to you then.
Charles Clay, TE -- SIT: He's second on the team in targets. With 36. In seven games. If you're not a mathematician, let us sum it up. It's not good.
New York Jets at Cleveland Browns: 1:00 p.m. ET on CBS
Quincy Enunwa, WR -- FLEX: Enunwa hasn't consistently been a player you'd consider starting. But this is a week where he could earn a look as the No. 2 target in the offense.
Josh McCown, QB -- SIT: It looks like he's back and ready to start again. That doesn't mean he has to start for your fantasy team this week.
San Diego Chargers at Denver Broncos: 4:05 p.m. ET on CBS
Philip Rivers, QB -- SIT: Rivers posted mediocre fantasy numbers when he last faced Denver, and that was in San Diego.
Melvin Gordon, RB -- START: Gordon has turned into the Cris Carter of running backs in 2016 -- all he does is score touchdowns. His 10 scores lead all backs, and there's no way to sit him given his volume, either.
Trevor Siemian, QB -- SIT: While Siemian has played really well in real life, he's topped 13.5 fantasy points just once this year. There are better streaming options available.
Green Bay Packers at Atlanta Falcons: 4:25 p.m. ET on FOX
Ty Montgomery, WR -- START: Montgomery is the only player in the NFL to have back-to-back 10 reception games in 2016. His role is growing in Green Bay, and fantasy owners should ride this wave as it rolls on.
Davante Adams, WR -- FLEX There's no way in hell Adams repeat's his impressive Week 8 performance. However, his nose for the end zone in 2016 (five touchdowns in six games) makes him worth a shot in the flex.
Tevin Coleman, RB -- SIT (INJURY): Even if Coleman "plays" this week, let him ride the fantasy pine. A hamstring injury for an explosive player like Coleman is the worst type of injury.
Julio Jones, WR -- START: One of the league's best wideouts against one of the worst secondaries. Julio could set records.