Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 5 fantasy matchups.
Atlanta Falcons at Denver Broncos: 4:05 p.m. ET on FOX
Julio Jones, WR -- START: If you're the type of person who can do anything but make Jones a must start after last week, even if the matchup is tough, well then that is your deal.
Cincinnati Bengals at Dallas Cowboys: 4:25 p.m. ET on CBS
Jeremy Hill, RB -- START: Hill is the running back you start and pray to the fantasy gods for a touchdown, because without one, he's not getting you the points needed. He's now gone 20 straight games without a 100-yards rushing, but his tendency to fall into the end zone keeps him afloat as a fantasy asset.
A.J. Green, WR -- START: Green leads the NFL with 32 receptions through four games. He is an elite fantasy option and is a must-start this week, as he was last week and will be every week going forward.
Dak Prescott, QB -- SIT: Over the last two weeks, Prescott is fantasy's second-highest scoring quarterback. It's a promising start, but matchups against the Bears and 49ers don't scream "difficult." This week against the Bengals, we'd be more cautious and roll with another more proven option with a better matchup.
Dez Bryant, WR -- SIT (INJURY): Dez will likely miss another game with a knee injury. But you knew that already, right?
Buffalo Bills at Los Angeles Rams: 4:25 p.m. ET on CBS
Charles Clay, TE -- SIT: With just 11.4 points through four weeks, Clay is a non-factor in fantasy. Even with Watkins out, he's not a startable option.
Tavon Austin, WR -- SIT: Dear Tavon, why you do dis? After posting 16 points in Week 3, Austin followed up with 0.8 in Week 4. He's simply not consistent enough to start unless you're in absolute dire straits.
San Diego Chargers at Oakland Raiders: 4:25 p.m. ET on CBS
Michael Crabtree, WR -- START: Is Crabtree the new No. 1 wide receiver for the Silver and Black? It sure looks that way as he leads the team in targets (37) and touchdowns (four). While he might only be a 1a to Cooper's 1b, if that, Crabtree's hot-start makes him worth a start.
Clive Walford, TE -- SIT: Even with several marquee tight ends on byes this week, look for a replacement elsewhere.
New York Giants at Green Bay Packers: 8:30 p.m. on NBC
Bobby Rainey, RB -- SIT: This backfield is back to it's frustrating committee ways. Steer clear until we have more clarity.
Eddie Lacy, RB -- FLEX: The team wanted to recommit to the ground game in Week 3, and Lacy saw a season-high 17 carries as a result, which he took for 103 yards (6.1 per carry). The Giants revamped defense line is stout though (3.39 ypc allowed to running backs), so Lacy feels like a better flex play this week.
Jordy Nelson, WR -- START: Nelson owns 28.7 percent of Rodgers' targets thus far and is still tied for the league-lead in red-zone targets (eight) even though he's coming off his bye. He's a low-end WR1 for Week 5.
Tampa Bay Buccaneers at Carolina Panthers: 8:30 p.m. ET on ESPN (Monday)
Cam Newton, QB -- START: The reigning MVP is questionable for Monday night. If he goes, however, he's in a tremendous spot. The Buccaneers pass defense ranks 27th in Football Outsiders' DVOA and they allow a 9-to-1 touchdown to interception ratio. Even if Derek Anderson has to play, he can post solid numbers.
Kelvin Benjamin, WR -- START: After two slower weeks Benjamin is in a prime blowup spot against an inferior and small group of Bucs corners. Even if Anderson starts, the volume will be there for Benjamin. He handled 21 targets in two games that Anderson started in 2014.
Arizona Cardinals at San Francisco 49ers: 8:25 p.m. ET on CBS/NFL Network (Thursday)
John Brown, WR -- FLEX: Brown had his biggest game of the season last week and looks healthy and dangerous once again. But can Stanton get it to him?
Blaine Gabbert, QB -- SIT: The talk in the Bay Area is that Gabbert is barely hanging on to his job. This isn't likely to be the week that he makes a positive statement.
Carlos Hyde, RB -- FLEX: Hyde looks like a good fit in Chip Kelly's uptempo, high-volume, run-heavy offense. Remaining involved even in garbage time has upped his stock.
Jeremy Kerley, WR -- FLEX: Kerley has far and away been the Niners best receiver. If they're playing from behind, he could see quite a few targets and be a nice PPR start.
Torrey Smith, WR -- SIT: Smith is the second-most targeted player on the roster, but fourth in receptions. It's hard to make a living as a deep threat against this defense.
Vance McDonald, TE -- SIT: It's possible that McDonald might not play this week. But even if he does, you can find better options on the waiver wire.
New England Patriots at Cleveland Browns: 1:00 p.m. ET on CBS
Julian Edelman, WR -- START: Few should be as excited about Brady's return as Edelman. He'll go back to being a targets machine with TB12 back in action.
Isaiah Crowell, RB -- START: Few are talking about how good Crowell has been this season. The matchup might not be good but the volume of touches makes him relevant.
Terrelle Pryor, WR -- FLEX: Pryor could have a rough go against New England, but he's the clear No. 1 receiver in this offense and should see a lot of targets.
Gary Barnidge, TE -- SIT: Barnidge has been all sorts of mediocre this season and has yet to find the end zone. His quarterback situation means he'll continue to be an untrustworthy start.
Philadelphia Eagles at Detroit Lions: 1:00 p.m. ET on FOX
Carson Wentz, QB -- START: Wentz has scored 19 or more fantasy points in two of his first three NFL contests and now faces the second-worst defense against fantasy quarterbacks.
Darren Sproles, RB -- START: Even before Mathews' injury, Sproles was dominating the backfield snaps and is the team leader in scrimmage yards.
Nelson Agholor, WR -- SIT: Agholor's made some nice individual plays but hasn't produced enough to warrant a spot in your lineup.
Matthew Stafford, QB -- SIT: Stafford failed to take advantage of a good matchup last week and now faces one of the league's tougher defenses.
Eric Ebron, TE -- SIT (INJURY): No team has given up fewer catches or yards to tight ends so far this season and Ebron is likely to be out while he recovers from multiple injuries.
Chicago Bears at Indianapolis Colts: 1:00 p.m. ET on FOX
Phillip Dorsett, WR -- SIT: Dorsett hasn't had more than six targets in any game and his snap share did not go up with Moncrief's injury. He's a boom-or-bust dart throw.
Tennessee Titans at Miami Dolphins: 1:00 p.m. ET on CBS
Derrick Henry, RB -- SIT: We still love Henry's talent, but he's simply not playing enough to be started in even the deepest of leagues.
Delanie Walker, TE -- START: Walker was pummeled with 27.6 percent of Mariota's targets in his return to action last week, but could only haul in two for 34 yards. Still, that's volume that simply cannot be ignored at a wasteland position like tight end.
Jarvis Landry, WR -- START: Landry has found the end zone just once, but has yet to see fewer than 10 targets in a game in 2016. He's a must-start in PPR formats, though he's safer as a flex in standard.
Washington Redskins at Baltimore Ravens: 1:00 p.m. ET on FOX
Jordan Reed, TE -- START: Reed finally found the end zone in Week 4 when (shockingly) Cousins targeted him in the red zone. Reed remains a locked-in TE1.
Joe Flacco, QB -- START: Flacco has been hit or miss so far in fantasy, but a potential shootout against Washington and it's pass-happy offense could be a recipe for fantasy success. He's worth streaming against a defense allowing over 8 yards per pass attempt.
Terrance West, RB -- START: West was given a shot at the starting role in Week 4 and ran away with it (21 attempts, 113 yards, touchdown). Washington allows the most rushing yards (532) and yards per carry (5.11) to running backs in the league. West should eat.
Steve Smith Sr., WR -- START: With 22 targets over the last two weeks, it's safe to say Triple S. is back. Bench him at your own peril.
Mike Wallace, WR -- LOW-END FLEX: Wallace averages 6.75 targets per game, but needs to find the end zone in order to be fantasy relevant. He hasn't hit the painted area since Week 2, so perhaps this is his week.
Houston Texans at Minnesota Vikings: 1:00 p.m. ET on CBS
Lamar Miller, RB -- START: Miller leads all running backs in touches (106) but has yet to find the end zone. His volume makes him a must-start, even in a tough matchup.
New York Jets at Pittsburgh Steelers: 1:00 p.m. ET on CBS
Ryan Fitzpatrick, QB -- SIT: Yeah, we're not falling for this one until Fitz figures out his turnover issues. Nine picks in the last two games is equivalent to negative 18 fantasy points in most leagues. Woof.
Matt Forte, RB -- FLEX: Right now, Forte is trending down in terms of his fantasy production since Week 1. He's still a decent option at running back though, and is good for anywhere from 15-20 touches per game. He's safe to start as a flex against a banged-up Pittsburgh defense.
Bilal Powell, RB -- FLEX:Powell took a backseat to Forte in the Jets first two games, but has seen his snap share rise in recent weeks. He's out-produced Forte in each of the last two games on fewer touches and seems to have an increasing role in a struggling Jets offense. His fantasy value may be game-script dependent so there is an inherent risk here, but the Jets may lean on him more as a pass-catcher with Decker sidelined.
Antonio Brown, WR -- START: Brown scored two touchdowns last week but had just 64 receiving yards. The last six times Brown has had fewer than 100 receiving yards in a game, he's responded with 100-plus in his next contest. Not like that matters. You're starting him.
Jesse James, TE -- SIT: James did score last week but had just two receptions. He hasn't had more than 31 yards in a game yet this year and should stay on your bench.
Sammie Coates, WR -- FLEX: Coates led the Steelers in targets and receiving yards among the teams' wideouts last week. There's a chance that he's coming around as a real weekly fantasy asset. We can see a situation where you throw him in your flex and he gets 70 yards and a touchdown against the Jets. Why not?