Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst remaining Week 1 fantasy matchups.
Pittsburgh Steelers at Washington Redskins: 7:10 p.m. ET on ESPN (Monday)
Sammie Coates, WR -- SIT: Coates had a disappointing offseason and won't see enough volume to be worthy of a fantasy start, at least not in Week 1.
Kirk Cousins, QB -- START: Cousins is a fringe QB1 as the season gets underway with a bevy of weapons to distribute the ball to. In a game that should be a shootout, he's a solid start for Week 1 even in 10-team leagues.
Redskins RBs -- SIT: Honestly you're better off avoiding this backfield in general, but if you drafted any of Washington's running backs, it's best to take a wait-and-see approach before rolling any member of this committee out as a fantasy starter.
DeSean Jackson, WR -- START: Jackson does have some boom-or-bust potential but since he's fully healthy, he'll be the No. 1 wideout for Washington to start the year. He can produce big numbers with a low-volume of targets, and in a game that could be a shootout, expect him to make some hay in primetime.
Jordan Reed, TE -- START: With the sorry situation at running back, Washington will likely lean on Reed in the red zone as they did last year. He's a must-start at tight end and a top-three option at the position heading into the season.
Los Angeles Rams at San Francisco 49ers: 10:20 p.m. ET on ESPN (Monday)
Todd Gurley, RB -- START: Gurley was probably an early first-round draft pick. You're not sitting him against the woeful Niners.
Tavon Austin, WR -- FLEX: Jeff Fisher says Austin will have a bigger role in the offense this year. Time to find out if he was telling the truth.
Blaine Gabbert, QB -- SIT: Yes, he's a starting quarterback. No, he doesn't belong in your lineup unless you're in a 16-team, 2-QB league.
Carlos Hyde, RB -- START: Hyde will be the most consistent starting option for the Niners this year. Look for him to shoulder a big workload.
Torrey Smith, WR -- FLEX: Smith was picking up steam as a deep sleeper as the summer progressed. He should see a lot of targets to start.
Vance McDonald, TE -- FLEX: McDonald is a sneaky play as a lower-tier tight end as someone who sees more targets than you'd think. If you're in a pinch, he's worth a shot.
Completed Week 1 Games
Carolina Panthers at Denver Broncos: 8:30 p.m. ET on NBC (Thursday)
Kelvin Benjamin, WR -- FLEX: Another situation where the matchup is bound to scare some owners off. Benjamin still projects to have plenty of volume in a game where Carolina will need to take advantage of any scoring chances they get.
Devin Funchess, WR -- SIT: We need to monitor Funchess in this game to see how his usage compares to the other receivers. We should wait until he's in more of a projected shootout before starting him in fantasy.
Panthers D/ST -- SIT: It might seem like a good idea against a new starting quarterback for Denver but a defense with a questionable secondary on the road against a slow-paced offense is not optimal for fantasy.
Virgil Green, TE -- SIT: A perennial breakout hopeful, Green finally looks like he'll be a big part of the offense after a strong preseason. However, we'll only use this game to monitor his usage in an effort to see if he's a sleeper moving forward.
Cleveland Browns at Philadelphia Eagles: 1:00 p.m. ET on CBS
Gary Barnidge, TE -- START:Few tight ends have the locked-in volume of Barnidge. The weeks during Gordon's suspension will be the prime weeks to roll him out.
Carson Wentz, QB -- SIT: There is not a scenario where you should consider playing Wentz in his first NFL game unless you play in a 2QB league. Even then, there's not much reason to believe this goes well.
Zach Ertz, TE -- SIT: You should have a better option than an inconsistent tight end in the red zone with a rookie under center.
Tampa Bay Buccaneers at Atlanta Falcons: 1:00 p.m. ET on FOX
Jameis Winston, QB -- START: Many are ready for a second-year jump this season. That should get off to a roaring start in what figures be a shootout in Atlanta.
Vincent Jackson, WR -- FLEX: Because this game could turn into a shootout, we like Jackson as a sneaky flex play.
Cameron Brate, TE -- SIT: We want to see how the tight end work splits up in Tampa Bay before using Brate, the presumed starter.
Matt Ryan, QB -- START: The veteran quarterback is coming off his worst season but this game features a nice chance to start off strong. The Bucs' secondary is weak and Ryan is at home in a potentially high-scoring game.
Devonta Freeman, RB -- START: He's a strong bet for four or five catches in any given week, but Freeman's pass-catching ability should be on full display in this contest.
Julio Jones, WR -- START:The Pro Bowler has a shot to be the top-scoring receiver on the board this weekend. The Bucs have a talent-deficient secondary and Jones could easily top 150 yards.
Green Bay Packers at Jacksonville Jaguars: 1:00 p.m. ET on FOX
Jordy Nelson, WR -- START: Since 2011, Nelson averages five receptions, .75 touchdowns, and 82 receiving yards per game when playing with Rodgers. Lock him in as a WR1.
Randall Cobb, WR -- START: Cobb might be the biggest beneficiary in Nelson's return to the lineup. Since 2012, he averages 25 more receiving yards per game with Nelson on the field, while seeing fewer targets. He could terrorize Jacksonville from the slot all game.
Blake Bortles, QB -- SIT: Bortles had a breakout year in 2015, but a date with the Packers young, talented secondary isn't an ideal matchup. Bortles scored many of his fantasy points playing from behind last year, which could be the case in Week 1, but our analysts have him as their QB15 this week. There are safer options with higher upside.
Chris Ivory, RB -- SIT (INJURY): Ivory was a surprise inactive for Week 1 after being admitted to the hospital for a general medical issue. He is doing well though per the team.
Allen Robinson, WR -- START: Robinson broke out in 2015 in a big way, but spent the whole offseason improving his craft. He's a no-brainer WR1 start.
Allen Hurns, WR -- FLEX: Hurns will be hard-pressed to finish with double-digit touchdowns once again, but in deeper leagues his big-play upside warrants consideration as a WR3.
Julius Thomas, TE -- START: Thomas disappointed last year, but has lost weight and received strong reviews this offseason. The Packers were middle-of-the-road against tight ends in 2015 and are starting at least one rookie starting linebacker (Blake Martinez). Thomas is worth a start as a low-end TE1.
Cincinnati Bengals at New York Jets: 1:00 p.m. ET on CBS
Giovani Bernard, RB -- FLEX: Bernard seemed likely to inherit many of the vacated targets from the departures of Marvin Jones and Mohamed Sanu, but the preseason didn't instill much confidence for us. Still, a matchup against the tough Jets defense could favor Bernard to see more work in hurry-up situations. He's a solid floor play in deeper leagues.
Brandon Marshall, WR -- START: Marshall saw nearly 29 percent of the passing game targets in 2015, and not much figures to change in that regard. His volume alone makes him worthy of a start.
Chicago Bears at Houston Texans: 1:00 p.m. ET on FOX
Jay Cutler, QB -- SIT: Cutler is breaking in a new No. 2 wide receiver against one of the league's best defenses that just welcomed back the league's best defensive player (J.J. Watt). Keep Smokin' Jay on the bench.
Alshon Jeffery, WR -- START: Jeffery was plagued by injuries in 2015, but saw 12 targets per game in contests where he played at least 75 percent of the snaps. He's Cutler's favorite target and a must-start regardless of the matchup.
Kevin White, WR -- SIT: White is still acclimating to the NFL and facing an elite NFL defense. With Jeffery siphoning loads of targets, White is better left on the bench until his role in this offense becomes clear.
DeAndre Hopkins, WR -- START: You were starting Nuk anyway, but the weakened Chicago secondary only makes him that much more of a no-brainer.
Minnesota Vikings at Tennessee Titans: 1:00 p.m. ET on FOX
Adrian Peterson, RB -- START: You're going to start the (arguably) best running back in the NFL no matter the matchup. The Vikes may tend to lean on Peterson early this season considering the shaky quarterback situation in Minnesota.
Kyle Rudolph, TE -- SIT: There are at least 14 other tight ends you can start before settling for Rudolph. Until he shows us something, leave him on the bench (or the waiver wire).
Jerick McKinnon, RB -- LOW-END FLEX: Even when Peterson is healthy, McKinnon could have some value as a third-down pass-catching option, especially if Minnesota finds themselves trailing. He's a flex play in deeper leagues.
Derrick Henry, RB -- FLEX: For now, Henry is the No. 2 back in Tennessee. Despite a great preseason, Henry will have to wait for his opportunity behind Murray, but his size advantage could lead to some goal-line chances. Throw him in your flex and hope for the best.
Rishard Matthews, WR -- FLEX: Matthews is the No. 1 receiver in Tennessee and is in line for decent volume out of the gate. He can be safely flexed in the majority of formats.
Buffalo Bills at Baltimore Ravens: 1:00 p.m. ET on CBS
Charles Clay, TE -- SIT: Clay probably wasn't drafted in your 10-team or even 12-team league. That means he's bench material. There are a number of other higher-upside tight ends to roll with in Week 1.
Reggie Bush, RB -- SIT: Bush probably won't have much of a role unless McCoy is sidelined. Leave him on your bench, or the waiver wire for now.
Joe Flacco, QB -- SIT: Flacco is coming off an ACL tear that ended his 2015 campaign and likely will have some rust to knock off. There are better options at quarterback for Week 1, especially when you consider the lackluster receiving corps he has at his disposal.
Oakland Raiders at New Orleans Saints: 1:00 p.m. ET on FOX
Amari Cooper, WR -- START: The AC/DC connection could get off to a rousing start with this game. Cooper could plant his flag as one of the top young fantasy wideouts.
Michael Crabtree, WR -- START: Don't forget about Crabtree in this potential track meet. He should at least get flex consideration.
Latavius Murray, RB -- START: If he really is Oakland's workhorse back, there's no time like the present to slide him into your starting lineup.
San Diego Chargers at Kansas City Chiefs: 1:00 p.m. ET on CBS
Philip Rivers, QB -- START: With a healthy offense around him, it wouldn't be a surprise to see Rivers throw the ball 40 times in the season opener.
Danny Woodhead, RB -- FLEX: This is more for PPR leagues as Woodhead might be a more effective backfield weapon than Gordon. Standard leagues should probably avoid.
Keenan Allen, WR -- START: At the beginning of what should be a big season, look for Allen to be pummeled with targets all throughout the ball game.
Antonio Gates, TE -- START: After Allen, expect Gates to see the next most targets on the roster this year. Plus, we're keeping an eye on how vigorously he chases the tight end touchdown record.
Travis Kelce, TE -- START: San Diego was fairly average against tight ends in 2015 and Kelce should be a big enough part of the passing game to warrant a Week 1 start.
Miami Dolphins at Seattle Seahawks: 4:05 p.m. ET on CBS
Jay Ajayi, RB -- LOW-END FLEX: Listed as the Dolphins No. 2 running back, Ajayi should see some work early on as Miami tries to set the tone. But once this game script gets out of hand, it will probably mean more looks for the team's wideouts. Flex Ajayi in 12-team or deeper leagues but you're better off with higher upside options in shallower formats.
DeVante Parker, WR -- SIT: Parker is still dealing with a hamstring injury that dogged him during the preseason and has not been able to practice. Look elsewhere for wideout production and leave Parker on the bench until he gets healthy.
Russell Wilson, QB -- START: If you own Wilson, you drafted him early on for a reason -- he's really good at football. He's a top-five option at quarterback week in and week out, especially because of the added points he provides with his legs.
Thomas Rawls, RB -- SIT: If we saw more of Rawls in the preseason, we might be more confident about his Week 1 status. He might see a few snaps, but the coaching staff is going to ease him back in. He's a very risky option.
Christine Michael, RB -- START:The Truth has been awakened in Seattle, and it's time for him to prove his worth. He'll have to play well in order to keep Rawls at bay, and is listed as the team's starting back for Week 1. He's a high-volume play and should be started against Miami.
Doug Baldwin, WR -- START:You probably drafted Baldwin as a WR2-3 and there's no reason to shy away from using him in that slot this week against a suspect Miami defense. He's Wilson's No. 1 target in what's becoming a more pass-heavy offense in Seattle so you can feel confident rolling Baldwin out in Week 1.
Tyler Lockett, WR -- FLEX:Lockett's upside is astronomical, but there are some concerns about his ability to produce on a weekly basis. In a favorable matchup against Miami, you can safely start Lockett as an upside flex play.
Detroit Lions at Indianapolis Colts: 4:25 p.m. ET on FOX
Anquan Boldin, WR -- SIT: Boldin could have a big role in this offense (and Cooter wants him to), but fantasy owners would be wise to take a "wait-and-see" approach with Boldin
Eric Ebron, TE -- START: Ebron is practicing in full despite his ankle injury, which is a good sign he'll play on Sunday. If he does suit up, he'll be a low-end TE1 in what figures to be a high-scoring game.
Andrew Luck, QB -- START: Throw out the 2015 game tape. Luck is a better quarterback than that. With healthy weapons alongside him against an average Detroit defense, Luck should be able to start his Comeback Player of the Year campaign with a bang.
Frank Gore, RB -- START: With no legitimate threat behind him on the depth chart, even if this game turns into a pass-happy affair Gore should still see enough touches to merit starting consideration in fantasy. He averaged over three targets per game with Luck under center in 2015.
T.Y. Hilton, Donte Moncrief, WRs -- START: Much like with Tate and Jones for the Lions, if you have Hilton or Moncrief you're playing them in Week 1. The Colts defense has holes all over the place from suspensions and injuries, which could put their offense into many passing situations to catch up. Hilton and Moncrief could both go off.
Dwayne Allen, TE -- START: With Coby Fleener out of the picture, Allen will be the primary tight end for the Colts. He re-signed with the team because new offensive coordinator Rod Chudzinski wants to feature him in a more prominent role. Again, in a high-scoring game you want as many parts of the passing offense as possible in your lineup, so Allen is definitely worth a start.
New York Giants at Dallas Cowboys: 4:25 p.m. ET on FOX
Eli Manning, QB -- START: You probably can't afford to risk sitting Manning in a game against a defense without a pass rush to speak of, but don't be surprised if Dallas' slow-paced offense takes opportunities away from him.
Rashad Jennings, RB -- START: If ever there was a time to ride Jennings it will be early in the season. With more volume locked in as the clear feature back, he should start off the year hot.
Odell Beckham, WR -- START:No further analysis needed. Dallas' lack of a pass rush should give Beckham plenty of chances to feast.
Will Tye, TE -- SIT: We need to see more of this tight end rotation before using any of them as a desperation play.
New England Patriots at Arizona Cardinals: 8:30 p.m. ET on NBC
Jimmy Garoppolo, QB -- SIT: There will be decent matchups coming for young Mr. Garoppolo. This isn't one of them.
Martellus Bennett, TE -- START: Bennett moves to a TE1 with Gronkowski on the shelf. Garoppolo targeted him regularly in the preseason. However, the matchup is less than ideal, so temper expectations and don't be afraid to start someone else over Bennett for this week.
Malcolm Mitchell, WR -- SIT: There is reason to be excited about the rookie this season, but it would be wise not to test him against Arizona's secondary.
David Johnson, RB -- START: A workhorse back in a potentially prolific offense. Right now, it's not about the matchups, it's about Johnson's talent.
Larry Fitzgerald, WR -- FLEX: Fitzgerald might not be the receiver he once was, but he's still pretty good and worthy of lineup consideration this week.