"Deep down inside, I hope not," Wayne said as the remaining fans in Lucas Oil Stadium chanted "Reggie! Reggie!" in appreciation. "I've been here 11 years. I don't see myself nowhere else, but I do understand the business of it. ... I'm going to treat it like a business, and after the season is over, we'll see what happens.
"I'm aware that I'm 33 years old, but I feel 23," Wayne added. "I feel great. If this is my last game, it's been a pleasure. These fans have been great to me from Day 1. They treated me like I'm a Hoosier."
Wayne, a five-time Pro Bowl receiver, will be a free agent after the season, and he speculated Wednesday that it's possible he won't be back with the Colts in 2012.
"It was pretty rough. On top of that, we had Kerry Collins, who really couldn't get the play out in time," Wayne said, taking a shot at the veteran quarterback the team signed after learning Manning likely would be out for the season.
Wayne was asked about his relationship with Orlovsky.
"I just walk past his locker and say, 'Just throw left,' " he said.