In one of the more enticing Week 1 matchups, New Orleans and Washington square off Sunday at the Superdome.
With Payton and linebacker Jonathan Vilma banned for the season and assistant head coach Joe Vitt (six games), general manager Mickey Loomis (eight games) and defensive end Will Smith (four games) suspended for their roles in New Orleans' bounty system, it remains to be seen if those off-the-field troubles will affect the Saints' on-field performance.
The team, though, isn't expecting any kind of drop off.
"There isn't a difference because we're following what Sean Payton has taught us. ... It is his program. It is the way he has done it. We've had a lot of success doing it his way. We think it is important that we continue to do that."
The Saints have made the playoffs four times during Payton's six years at the helm, including each of the last three seasons. The 2009 Super Bowl champions went 13-3 last year before beating Detroit 45-28 in the wild-card round and suffering a last-second 36-32 divisional-round loss at San Francisco.
"We've established a culture here that everyone has bought into, and when you've established a culture, no matter who's at the top of it, it's always the same," safety Malcolm Jenkins said. "The Saints organization is not about Sean Payton. It's not about Mickey Loomis. It's not about Joe Vitt or a certain person. The New Orleans Saints have a culture in what we do.
"The pressure is on us, at least internally, to have this be a huge year. I think everyone knows the importance of it and how huge of a deal that would be for us to get that Super Bowl."
"I am excited about our team. I am excited about our opportunity. It's really the focus of one week at a time just trying to get a little bit better each time you step on the field," said Brees, who signed a five-year, $100 million contract during the offseason.
"I couldn't be more excited about where we are at and where we are headed."
For the first time in a long while, Redskins faithful are also expecting big things from their quarterback. After losing 10 of its final 12 games to finish 5-11 last season, Washington traded the No. 6 pick in the draft, two future first-round picks and a second-rounder to St. Louis for a chance to move up and take Griffin second overall.
"He's still a young kid. He still has a lot to learn," cornerback DeAngelo Hall said of the former Baylor standout. "We still have a lot of weapons we need to put around him, too, but we feel like we have adequate guys around him, a lot of playmakers to where we can definitely make that transition a little bit easier for him."
The Redskins signed Pierre Garcon to a five-year, $42.5 million deal and also brought in fellow receiver Josh Morgan. Fred Davis, who finished second on the team with 59 receptions and 796 yards despite missing four games last season, could be in line for an even bigger role following longtime tight end Chris Cooley's release last week.
Despite the Redskins' recent woes, Griffin appears up to the task of trying to lead his team back to respectability. Since making its most recent playoff appearance in 2007, Washington has gone 23-41 over the last four seasons.
"Last time I checked, they still have us fourth in the NFC East," the reigning Heisman Trophy winner said. "And not that we care, but we're going to go out and try to make sure that we're not."
Washington has gone 15-8 against New Orleans, winning eight of 11 on the road. The Saints took the last matchup 33-30 in overtime Dec. 6, 2009, in the nation's capital.
Washington, though, will be without Tanard Jackson (suspended indefinitely) and fellow safety Brandon Meriweather, who's expected to miss at least two weeks with a sprained MCL and PCL.
Copyright 2012 by The Associated Press