Henderson fractured his femur while trying to tackle Tim Hightower late in the fourth quarter -- his leg twisting violently as he went down. He was taken off the field on a motorized cart after doctors spent several minutes attending to the star linebacker. His brother and teammate, Erin, held Henderson's hand as they were driven to the locker room.
Henderson has been a key part of Minnesota's defensive success this season, and it was the second straight year that his season was cut short with injury.
The mood in the locker room around the Henderson injury was somber as many players just shook their heads in disgust at the horrific injury.
"I feel bad for E.J.," Vikings quarterback Brett Favre said. "That's awful for him and for our team."
Copyright 2009 by The Associated Press