The Bills built a 24-0 lead by scoring on four consecutive possessions into the third quarter. And Buffalo's defense did the rest.
The retooled Luck-led Colts attack was limited to 148 yards offense and nine first downs on its first five drives before scoring two touchdowns in the final 16 minutes.
Luck finished 26 of 49 for 243 yards and two touchdowns, and was intercepted twice.
Copyright 2015 by The Associated Press