The Titans running back was reportedly spotted in a walking boot during Friday's workout. Henry has since missed practice.
NFL Network Insider Ian Rapoport reported Tennessee is "not worried" about the injury and Henry's issue "should not be a big deal."
"No one seems worried at all about the status of Derrick Henry despite the fact that he hasn't been out there the last couple days," Rapoport said on Inside Training Camp Live on Sunday. "This (injury) is described to me as minor and should not be something that either, one, is long term at all or, two, something that keeps him out for a long time."
Any time missed would be noteworthy for one of the league's top rushers last season. The fourth-year back is coming off his best campaign, posting career highs in rushing yards (1,059), yards per carry (4.9) and touchdowns (12) in his first season as a regular starter.