Having practiced through the week, Simmons is now set to make his NFL debut, though Rapoport added the Titans will be cautious in his return.
Through the season so far, Simmons was on the non-football injury list.
The ACL tear took place in February, so Simmons, 22, is in the midst of an amazing return. On Wednesday, Simmons practiced for the first time and was a participant through Friday.
As a college junior, the defensive tackle had 63 tackles, 18 for a loss and two sacks in 13 games.